{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:02:23Z","timestamp":1787238143885,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,4,20]],"date-time":"2011-04-20T00:00:00Z","timestamp":1303257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>\n                    <jats:bold>Abstract:\u2002<\/jats:bold>\n                    Oestrogen deprivation is one of the major factors responsible for many age\u2010related processes, including poor wound healing in women. Previously, it has been shown that oestrogens have a modulatory effect in different wound\u2010healing models. Therefore, in this study, the effect of selective oestrogen receptor (ER) agonists (PPT \u2013 ER\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    agonist, DPN \u2013 ER\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    agonist) on excisional and incisional wound\u2010healing models was compared in ovariectomised rats\n                    <jats:italic>in vivo<\/jats:italic>\n                    as well as on human dermal fibroblasts (HDF) and human umbilical endothelial cells (HUVEC)\n                    <jats:italic>in vitro<\/jats:italic>\n                    . In the\n                    <jats:italic>in vivo<\/jats:italic>\n                    study, 4\u2003months after either ovariectomy or sham ovariectomy, Sprague\u2010Dawley rats were randomly divided into four groups and subjected to two incisional and excisional wounds: (i) control \u2013 sham operated, vehicle\u2010treated; (ii) ovariectomised, vehicle\u2010treated; (iii) ovariectomised, PPT treated; (iv) ovariectomised, DPN treated. In the\n                    <jats:italic>in vitro<\/jats:italic>\n                    study, HDFs and HUVECs were used. After treatment with ER agonists, cells were processed for immunocytochemistry and gelatin zymography. Our study shows that stimulation of ER\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    leads to the differentiation of fibroblasts into myofibroblasts both\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    . On the other hand, the formation of extracellular matrix was more prominent, and wound tensile strength (TS) was increased when ER\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    was stimulated. In contrast, stimulation of ER\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    led to a more prominent increase in the expression of MMP\u20102 and decrease in wound TS\n                    <jats:italic>.<\/jats:italic>\n                    New information is presented in this investigation concerning oestrogen replacement therapy (ERT) in different wound\u2010healing models. This study demonstrates that the ERT should be both wound and receptor\u2010type specific.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0625.2011.01284.x","type":"journal-article","created":{"date-parts":[[2011,4,20]],"date-time":"2011-04-20T22:35:50Z","timestamp":1303338950000},"page":"703-708","source":"Crossref","is-referenced-by-count":29,"title":["ER\u2010\u03b1 agonist induces conversion of fibroblasts into myofibroblasts, while ER\u2010\u03b2 agonist increases ECM production and wound tensile strength of healing skin wounds in ovariectomised 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