{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:28:31Z","timestamp":1791919711268,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,5,16]],"date-time":"2011-05-16T00:00:00Z","timestamp":1305504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold>Microphthalmia\u2010associated transcription factor (MITF) is inducible in response to cAMP through the cAMP\u2010responsive element\u2013binding protein (CREB) and plays a pivotal role in the melanocyte\u2010specific expression of tyrosinase or tyrosinase\u2010related proteins (TRPs) for melanin biosynthesis. Manassantin A from<jats:italic>Saururus chinensis<\/jats:italic>inhibits cAMP\u2010induced melanin production in B16 melanoma cells. Here, we focused on molecular basis of the antimelanogenic activity. Manassantin A consistently inhibited the cAMP elevator 3\u2010isobutyl\u20101\u2010methylxanthine (IBMX)\u2010 or dibutyryl cAMP\u2010induced melanin production in B16 cells or in melan\u2010a melanocytes by down\u2010regulating the expression of<jats:italic>tyrosinase<\/jats:italic>or<jats:italic>TRP1<\/jats:italic>gene. Moreover, manassantin A suppressed MITF induction through IBMX\u2010activated CREB pathway, directly inhibiting the Ser\u2010133 phosphorylation of CREB. However, manassantin A did not affect IBMX\u2010increased cAMP levels in these cells but also other cAMP\u2010dependent melanogenic pathways through post\u2010translational modifications of MITF. This putative molecular mechanism of manassantin A in the inhibition of melanin production suggests its pharmacological potential in skin hyperpigmentation.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2011.01296.x","type":"journal-article","created":{"date-parts":[[2011,5,16]],"date-time":"2011-05-16T08:34:15Z","timestamp":1305534855000},"page":"761-763","source":"Crossref","is-referenced-by-count":25,"title":["Manassantin A inhibits cAMP\u2010induced melanin production by down\u2010regulating the gene expressions of MITF and tyrosinase in melanocytes"],"prefix":"10.1111","volume":"20","author":[{"given":"Hwa 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