{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:36:50Z","timestamp":1778776610937,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,5,25]],"date-time":"2011-05-25T00:00:00Z","timestamp":1306281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> We investigated the involvement of MAPK pathways in the melanogenic effect of apigenin in B16 cells. Apigenin treatment for 48\u2003h dose (5\u201320\u2003\u03bc<jats:sc>m<\/jats:sc>)\u2010dependently up\u2010regulated protein expression levels of microphthalmia\u2010associated transcription factor (MITF) and melanogenic enzymes including tyrosinase, tyrosinase\u2010related protein\u20101 (TRP\u20101) and TRP\u20102 and enhanced the phosphorylation of p38 MAPK, without affecting the phosphorylation of JNK or ERK MAPK. Treatment with 10\u2003\u03bc<jats:sc>m<\/jats:sc> apigenin time (6\u201048\u2003h)\u2010dependently elevated the protein expressions of p\u2010p38, MITF and melanogenic enzymes. Moreover, PD169316, a selective inhibitor of p38 kinase, suppressed the stimulatory effects of apigenin on tyrosinase activity and melanin synthesis, which were accompanied by decreased MITF protein expression. In conclusion, apigenin increased melanogenesis in B16 cells, at least in part, by activating the p38 MAPK pathway. The novel findings of this study shed light on the molecular mechanisms underlying the melanogenic activity of apigenin and suggest that apigenin\/its derivatives may be potentially used for treating hypopigmentation disorders.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2011.01297.x","type":"journal-article","created":{"date-parts":[[2011,5,25]],"date-time":"2011-05-25T13:55:29Z","timestamp":1306331729000},"page":"755-757","source":"Crossref","is-referenced-by-count":38,"title":["Activation of p38 MAPK pathway contributes to the melanogenic property of apigenin in B16 cells"],"prefix":"10.1111","volume":"20","author":[{"given":"Yan","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Hong","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui\u2010Xin","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Ling","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,5,25]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jidsp.5640176"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06925.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.00017.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01726-9"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.04.046"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.30.180"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00794.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.09.007"},{"key":"e_1_2_7_10_2","first-page":"233","volume":"30","author":"Patel D","year":"2007","journal-title":"Int J Oncol"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2010.06.004"},{"key":"e_1_2_7_12_2","first-page":"92","volume":"1","author":"Ye Y","year":"2011","journal-title":"Integr Cancer Ther"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19607.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2009.07.016"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00348.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(96)00212-X"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0625.2011.01297.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0625.2011.01297.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T02:46:04Z","timestamp":1697337964000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0625.2011.01297.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,25]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1111\/j.1600-0625.2011.01297.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0625.2011.01297.x","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,25]]}}}