{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:33:12Z","timestamp":1791405192641,"version":"4.3.3"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,12]],"date-time":"2011-12-12T00:00:00Z","timestamp":1323648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Despite recent developments, there is a high medical need for new treatment options for chronic inflammatory dermatoses like allergic contact dermatitis (ACD) and psoriasis. Particularly, more predictive skin inflammation models are required to facilitate the process of drug discovery. Murine contact hypersensitivity (CHS) models adequately reflect ACD and are also used to characterize therapeutic approaches for psoriasis. Using the hapten 2,4\u2010dinitrofluorobenzene (DNFB), we established new subacute and subchronic DNFB\u2010induced CHS models in C57BL\/6 mice, which more closely reflect the characteristics of chronic T\u2010cell\u2010dependent inflammatory dermatoses as pronounced keratinocyte proliferation, strong hypervascularization, immune cell infiltration and overexpression of T cell and inflammatory cytokines. For the subacute DNFB model, we demonstrated anti\u2010inflammatory activity of the glucocorticoid, prednisolone, as well as of neutralization of TNF\u03b1, IL\u201012\/IL\u201023 or IL\u201018. In the subchronic DNFB\u2010induced CHS model, deficiency for MyD88 and IL\u201012\/IL\u201035 p35 chain but not IL\u201012\/IL\u201023 p40 chain led to decreased skin inflammation. Furthermore, as exemplified by the dose\u2010dependently effective therapeutic prednisolone treatment, the subchronic model allows the continuous therapy of a pre\u2010established stable contact dermatitis. Altogether, prolonged DNFB\u2010induced mouse CHS models closely reflect ACD sensitive to glucocorticoids as standard therapy, reveal a more chronic skin inflammation and are responsive to cytokine antagonization.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2011.01395.x","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T18:00:50Z","timestamp":1318356050000},"page":"25-31","source":"Crossref","is-referenced-by-count":37,"title":["Extended DNFB\u2010induced contact hypersensitivity models display characteristics of chronic inflammatory 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