{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:52:34Z","timestamp":1792705954204,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,12]],"date-time":"2011-12-12T00:00:00Z","timestamp":1323648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold>The effects of the histamine H<jats:sub>4<\/jats:sub>receptor antagonist JNJ7777120 were evaluated in a model of acute skin inflammation induced by local application of croton oil. The influence of strain on the effect of JNJ7777120 was investigated in four different mouse strains (CD\u20101, NMRI, BALB\/c and C57BL\/6J). In CD\u20101 mice, JNJ777720 (30\u2013100\u2003mg\/kg subcutaneously, s.c.) exerted a dose\u2010dependent inhibition of croton oil\u2010induced ear inflammation and polymorphonuclear leucocyte infiltration, as confirmed by histological evaluation of ear tissues. JNJ7777120 (30\u2013100\u2003mg\/kg) did not reduce ear oedema in NMRI, BALB\/c or C57BL\/6J mice. The positive control, dexamethasone (2\u2003mg\/kg s.c.) induced significant anti\u2010inflammatory effects only in CD\u20101 and NMRI mice. In these strains, also the histamine H<jats:sub>1<\/jats:sub>\u2010receptor blocker pyrilamine (30\u2003mg\/kg s.c.) significantly reduced ear oedema at 2\u2003h after croton oil challenge, being as effective as JNJ7777120 in CD\u20101 mice. Taken together, these data demonstrate that the H<jats:sub>4<\/jats:sub>receptor antagonist JNJ7777120 may reduce acute croton oil\u2010induced skin inflammation as effectively as H<jats:sub>1<\/jats:sub>receptor blockade. However, present experiments evidenced for the first time marked strain\u2010related differences in the JNJ7777120 pharmacological activity, which have to be carefully considered when using this ligand to characterize histamine H<jats:sub>4<\/jats:sub>receptor functions in murine models and translating preclinical data to clinical human settings.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2011.01396.x","type":"journal-article","created":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T14:33:13Z","timestamp":1318861993000},"page":"32-37","source":"Crossref","is-referenced-by-count":29,"title":["Strain\u2010dependent effects of the histamine H<sub>4<\/sub>receptor antagonist JNJ7777120 in a murine model of acute skin 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