{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:36:25Z","timestamp":1789436185280,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Interferon\u2010\u03b3 (IFN\u03b3)\u2010induced collapse of hair follicle (HF) immune privilege (IP) is a key element in the pathogenesis of alopecia areata. In this pilot study, we investigated whether the immunosuppressive neuropeptide, calcitonin gene\u2010related peptide (CGRP), can protect from and\/or restore IFN\u03b3\u2010induced HF\u2010IP collapse. After showing that human scalp HFs express CGRP receptor\u2010like receptor (CRLR) immunoreactivity, anagen HFs were cultured in the presence of IFN\u03b3, with CGRP added before or after. Adding CGRP after IFN\u03b3 administration (\u2018restoration assay\u2019) failed to downregulate IFN\u03b3\u2010induced ectopic MHC class I expression, while MHC class II expression was reduced. However, administering CGRP before IFN\u03b3 application (\u2018protection assay\u2019) significantly reduced the IFN\u03b3\u2010induced overexpression and ectopic expression of MHC class I and II and reduced the increased degranulation of perifollicular mast cells induced by IFN\u03b3. This suggests that CGRP may not restore HF\u2010IP once it has collapsed, but may protect it from collapsing. Therefore, CRLR stimulation might help to retard AA progression.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2011.01432.x","type":"journal-article","created":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T07:39:32Z","timestamp":1323934772000},"page":"223-226","source":"Crossref","is-referenced-by-count":61,"title":["Calcitonin gene\u2010related peptide (CGRP) may award relative protection from interferon\u2010\u03b3\u2010induced collapse of human hair follicle immune 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