{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:12:29Z","timestamp":1789981949710,"version":"4.0.1"},"reference-count":58,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T00:00:00Z","timestamp":1331769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> The S100 fused\u2010type proteins (SFTPs) are thought to be involved in the barrier formation and function of the skin. Mutations in the <jats:italic>profilaggrin<\/jats:italic> gene, one of the best investigated members of this family, are known to be the major risk factors for ichthyosis vulgaris and atopic dermatitis. Recently, we identified human filaggrin\u20102 as a new member of the SFTP family. To achieve further insight into its function, here the murine filaggrin\u20102 was analysed as a possible orthologue. The 5\u2032 and 3\u2032 ends of the mouse filaggrin\u20102 cDNA of the BALB\/c strain were sequenced and confirmed an organization typical for SFTPs. Murine filaggrin\u20102 showed an expression pattern mainly in keratinizing epithelia in the upper cell layers on both mRNA and protein levels. The expression in cultured mouse keratinocytes was increased upon elevated Ca<jats:sup>2+<\/jats:sup> levels. Immunoblotting experiments indicated an intraepidermal processing of the 250\u2010kDa full\u2010length protein. In metabolically (essential fatty acid\u2010deficient diet) induced skin barrier dysfunction, <jats:italic>filaggrin\u20102<\/jats:italic> expression was significantly reduced, whereas <jats:italic>filaggrin<\/jats:italic> expression was up\u2010regulated. In contrast, mechanical barrier disruption with acetone treatment did not affect <jats:italic>filaggrin\u20102<\/jats:italic> mRNA expression. These results suggest that filaggrin\u20102 may contribute to epidermal barrier function and its regulation differs, at least in parts, from that of filaggrin.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2012.01449.x","type":"journal-article","created":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T20:05:46Z","timestamp":1326830746000},"page":"271-276","source":"Crossref","is-referenced-by-count":33,"title":["Murine filaggrin\u20102 is involved in epithelial barrier function and down\u2010regulated in metabolically induced skin barrier dysfunction"],"prefix":"10.1111","volume":"21","author":[{"given":"Britta","family":"Hansmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Ahrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehrhardt","family":"Proksch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Meyer\u2010Hoffert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens\u2010Michael","family":"Schr\u00f6der","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,15]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(89)90132-8"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1993.1430"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12338501"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23699.x"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00266a033"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12540769"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00583a016"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(77)90250-1"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.102.4.1419"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.71"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4818"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23675.x"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107512200"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409026200"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23694.x"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005227"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2007-8-6-r107"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.07.096"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.30.17702"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(83)90336-9"},{"key":"e_1_2_8_22_2","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1016\/S0021-9258(19)85876-3","volume":"255","author":"Lonsdale\u2010Eccles J D","year":"1980","journal-title":"J Biol Chem"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1767"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.10.046"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.347"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.033"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.197400"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm404"},{"key":"e_1_2_8_29_2","first-page":"14","volume":"4","author":"Nicholas K B","year":"1997","journal-title":"Embnet.news"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.5857"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0134(20001101)41:2<224::AID-PROT70>3.0.CO;2-Z"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1992.tb00189.x"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00960-4.x"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(77)90059-9"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12712202"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115183"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12650440"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.272"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.033969"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2001.5348"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12334205"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01831.x"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.00133.x"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-679X(04)78028-0"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-2494.2000.00001.x"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12398620"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(82)90314-2"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02505232"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700365"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700459"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.05.004"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00786.x"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01203.x"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.29"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.04.038"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12461361"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(83)90058-9"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00318.x"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0625.2012.01449.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0625.2012.01449.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T16:22:11Z","timestamp":1698682931000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0625.2012.01449.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,15]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1111\/j.1600-0625.2012.01449.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0625.2012.01449.x","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,15]]}}}