{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:51:28Z","timestamp":1793299888224,"version":"4.5.0"},"reference-count":161,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,4,16]],"date-time":"2012-04-16T00:00:00Z","timestamp":1334534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>\n                    <jats:bold>Abstract:\u00a0<\/jats:bold>\n                    The skin is essential for survival and protects our body against biological attacks, physical stress, chemical injury, water loss, ultraviolet radiation and immunological impairment. The epidermal barrier constitutes the primordial frontline of this defense established during terminal differentiation. During this complex process proliferating basal keratinocytes become suprabasally mitotically inactive and move through four epidermal layers (basal, spinous, granular and layer, stratum corneum) constantly adapting to the needs of the respective cell layer. As a result, squamous keratinocytes contain polymerized keratin intermediate filament bundles and a water\u2010retaining matrix surrounded by the cross\u2010linked cornified cell envelope (CE) with ceramide lipids attached on the outer surface. These cells are concomitantly insulated by intercellular lipid lamellae and hold together by corneodesmosmes. Many proteins essential for epidermal differentiation are encoded by genes clustered on chromosomal human region 1q21. These genes constitute the \u2018epidermal differentiation complex\u2019 (EDC), which is divided on the basis of common gene and protein structures, in three gene families: (i) CE precursors, (ii) S100A and (iii) S100 fused genes. EDC protein expression is regulated in a gene and tissue\u2010specific manner by a pool of transcription factors. Among them, Klf4, Grhl3 and Arnt are essential, and their deletion in mice is lethal. The importance of the EDC is further reflected by human diseases: FLG mutations are the strongest risk factor for atopic dermatitis (AD) and for AD\u2010associated asthma, and faulty CE formation caused by TG1 deficiency causes life\u2010threatening lamellar ichthyosis. Here, we review the EDC genes and the progress in this field.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0625.2012.01472.x","type":"journal-article","created":{"date-parts":[[2012,2,17]],"date-time":"2012-02-17T13:02:23Z","timestamp":1329483743000},"page":"643-649","source":"Crossref","is-referenced-by-count":315,"title":["The human epidermal differentiation complex: cornified envelope precursors, S100 proteins and the \u2018fused genes\u2019 family"],"prefix":"10.1111","volume":"21","author":[{"given":"Magdalini","family":"Kypriotou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Hohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05659"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.23.090506.123357"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1242\/jcs.114.17.3069","volume":"114","author":"Kalinin A","year":"2001","journal-title":"J Cell Sci"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2009.04.001"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22515.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.249"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.125310"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607567200"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41440"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-009-0045-6"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23547.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12463281"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/emm.1999.2"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)38163-8"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.231"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010157200"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12275357"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-008-0123-9"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01853.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7824952"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12324122"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.34.21018"},{"key":"e_1_2_6_24_2","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1159\/000484767","volume":"5","author":"Petit E","year":"1997","journal-title":"Eur J Hum Genet"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1086\/497707"},{"key":"e_1_2_6_26_2","author":"Pavlovic S","year":"2011","journal-title":"Pediatr Dermatol"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(07)80013-2"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12338501"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1092-91"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4952"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.231489198"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2001.6518"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23699.x"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22719.x"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.07.096"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00114a013"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4818"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23694.x"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23675.x"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409026200"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005227"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.71"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12354504"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1993.1240"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.22.10754"},{"issue":"2","key":"e_1_2_6_46_2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1242\/jcs.107.2.693","volume":"107","author":"Steven A C","year":"1994","journal-title":"J Cell Sci"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90884-6"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(79)90123-5"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12413482"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12472288"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.28.17763"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.151.2.381"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200706187"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22723.x"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2007.11.006"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/1047-8477(90)90071-J"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90073-N"},{"key":"e_1_2_6_58_2","first-page":"299","volume":"41","author":"Hohl D","year":"1990","journal-title":"Hautarzt"},{"key":"e_1_2_6_59_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1432-0436.1993.tb01585.x","volume":"54","author":"Hohl D","year":"1993","journal-title":"Differentiation"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199302000-00004"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205593200"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.18.10792"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12469779"},{"key":"e_1_2_6_64_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.151.2.389"},{"key":"e_1_2_6_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0596-70"},{"key":"e_1_2_6_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(02)00143-3"},{"key":"e_1_2_6_67_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22431.x"},{"key":"e_1_2_6_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.10144"},{"key":"e_1_2_6_69_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.151.2.401"},{"key":"e_1_2_6_70_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12606176"},{"key":"e_1_2_6_71_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100336200"},{"key":"e_1_2_6_72_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12612759"},{"key":"e_1_2_6_73_2","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1242\/jcs.114.21.3837","volume":"114","author":"Cabral A","year":"2001","journal-title":"J Cell Sci"},{"key":"e_1_2_6_74_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011957"},{"key":"e_1_2_6_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.433"},{"key":"e_1_2_6_76_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.291.5505.881"},{"key":"e_1_2_6_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600454"},{"key":"e_1_2_6_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.12.017"},{"key":"e_1_2_6_79_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.077552"},{"key":"e_1_2_6_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.313"},{"key":"e_1_2_6_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.90"},{"key":"e_1_2_6_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2011.05.028"},{"key":"e_1_2_6_83_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215540305100513"},{"key":"e_1_2_6_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03963"},{"key":"e_1_2_6_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.158"},{"key":"e_1_2_6_86_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0666-4"},{"key":"e_1_2_6_87_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.432"},{"key":"e_1_2_6_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.05.017"},{"key":"e_1_2_6_89_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.033969"},{"key":"e_1_2_6_90_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01831.x"},{"key":"e_1_2_6_91_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12333356"},{"key":"e_1_2_6_92_2","first-page":"1245","volume":"78","author":"Ishida\u2010Yamamoto A","year":"1998","journal-title":"Lab Invest"},{"key":"e_1_2_6_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng2020"},{"key":"e_1_2_6_94_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00178.x"},{"key":"e_1_2_6_95_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200304161"},{"key":"e_1_2_6_96_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200501038"},{"key":"e_1_2_6_97_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.311"},{"key":"e_1_2_6_98_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.090240"},{"key":"e_1_2_6_99_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1162"},{"key":"e_1_2_6_100_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12334205"},{"key":"e_1_2_6_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.12.009"},{"key":"e_1_2_6_102_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011040"},{"key":"e_1_2_6_103_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.115"},{"key":"e_1_2_6_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.231"},{"key":"e_1_2_6_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(01)00136-0"},{"key":"e_1_2_6_106_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.135.6.1879"},{"key":"e_1_2_6_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2010.11.001"},{"key":"e_1_2_6_108_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1743"},{"key":"e_1_2_6_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.01.031"},{"key":"e_1_2_6_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2006.07.013"},{"key":"e_1_2_6_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.01.051"},{"key":"e_1_2_6_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.01.026"},{"key":"e_1_2_6_113_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.358"},{"key":"e_1_2_6_114_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090957"},{"key":"e_1_2_6_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.06.046"},{"key":"e_1_2_6_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.042"},{"key":"e_1_2_6_117_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1994.1522"},{"key":"e_1_2_6_118_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2007-8-6-r107"},{"key":"e_1_2_6_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.033"},{"key":"e_1_2_6_120_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.102.4.1419"},{"key":"e_1_2_6_121_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.44.27893"},{"key":"e_1_2_6_122_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12470590"},{"key":"e_1_2_6_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)50322-2"},{"key":"e_1_2_6_124_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.121.4.855"},{"key":"e_1_2_6_125_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.48.30709"},{"key":"e_1_2_6_126_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00777.x"},{"key":"e_1_2_6_127_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2000.6344"},{"key":"e_1_2_6_128_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2006.05206.x"},{"key":"e_1_2_6_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2005.02.005"},{"key":"e_1_2_6_130_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1577"},{"key":"e_1_2_6_131_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-69"},{"key":"e_1_2_6_132_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01856.x"},{"key":"e_1_2_6_133_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302037200"},{"key":"e_1_2_6_134_2","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1242\/dev.129.7.1775","volume":"129","author":"Turksen K","year":"2002","journal-title":"Development"},{"key":"e_1_2_6_135_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107512200"},{"key":"e_1_2_6_136_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.370"},{"key":"e_1_2_6_137_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-168658"},{"key":"e_1_2_6_138_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.120.1.217"},{"key":"e_1_2_6_139_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.10.5365"},{"key":"e_1_2_6_140_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.21.4287"},{"key":"e_1_2_6_141_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00071.x"},{"key":"e_1_2_6_142_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.39.24105"},{"key":"e_1_2_6_143_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.38.24683"},{"key":"e_1_2_6_144_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.24"},{"key":"e_1_2_6_145_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28521"},{"key":"e_1_2_6_146_2","doi-asserted-by":"publisher","DOI":"10.1038\/11926"},{"key":"e_1_2_6_147_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00477"},{"key":"e_1_2_6_148_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608658103"},{"key":"e_1_2_6_149_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200605057"},{"key":"e_1_2_6_150_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1107511"},{"key":"e_1_2_6_151_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.07.015"},{"key":"e_1_2_6_152_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.03282"},{"key":"e_1_2_6_153_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.568810"},{"key":"e_1_2_6_154_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.119"},{"key":"e_1_2_6_155_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1248"},{"key":"e_1_2_6_156_2","author":"Sch\u00e4fer M","year":"2012","journal-title":"EMBO Mol Med"},{"key":"e_1_2_6_157_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.037010"},{"key":"e_1_2_6_158_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M512116200"},{"key":"e_1_2_6_159_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1089403"},{"key":"e_1_2_6_160_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-0755"},{"key":"e_1_2_6_161_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506119200"},{"key":"e_1_2_6_162_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01188.x"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0625.2012.01472.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0625.2012.01472.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:50:38Z","timestamp":1695484238000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0625.2012.01472.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,16]]},"references-count":161,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1600-0625.2012.01472.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0625.2012.01472.x","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,16]]}}}