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In this study, we investigated similarities in the gene expression profiles of each subtype on<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>level. Type XVI collagen (<jats:styled-content style=\"fixed-case\">COL<\/jats:styled-content>16<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>1),<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>0\/<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>1 switch 2 (<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>0<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>2), fibronectin (<jats:styled-content style=\"fixed-case\">FN<\/jats:styled-content>1), ribosomal protein<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>27<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">RPS<\/jats:styled-content>27<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>) and low density lipoprotein receptor (<jats:styled-content style=\"fixed-case\">LDLR<\/jats:styled-content>) were shown to exhibit corresponding changes in gene expression in all three<jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content>subtypes. While<jats:styled-content style=\"fixed-case\">COL<\/jats:styled-content>16<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>1,<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>0<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>2 and<jats:styled-content style=\"fixed-case\">FN<\/jats:styled-content>1 are up\u2010regulated,<jats:styled-content style=\"fixed-case\">LDLR<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">RPS<\/jats:styled-content>27A<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>levels are decreased. These data indicate that EB cells seem to take measures increasing their mechanical stability. Apoptosis is likely to be exacerbated, and migratory potential appears to be elevated. Protein degradation is hampered, and the release of fatty acids and glycerol is restricted, probably to save energy. These commonalities might benefit existing EB treatment strategies or could help to reveal new starting points for the treatment of EB in the future.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2012.01519.x","type":"journal-article","created":{"date-parts":[[2012,4,30]],"date-time":"2012-04-30T06:28:43Z","timestamp":1335767323000},"page":"526-530","source":"Crossref","is-referenced-by-count":15,"title":["Epidermolysis bullosa \u2013 a group of skin diseases with different causes but commonalities in gene expression"],"prefix":"10.1111","volume":"21","author":[{"given":"Julia","family":"Knaup","sequence":"first","affiliation":[{"name":"Department of Molecular Biology University of Salzburg Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Verwanger","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology University of Salzburg Salzburg 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