{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:22:19Z","timestamp":1791145339256,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,7,10]],"date-time":"2012-07-10T00:00:00Z","timestamp":1341878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"Abstract<\/jats:title>Brm is an ATP<\/jats:styled-content>ase subunit of the SWI<\/jats:styled-content>\/SNF<\/jats:styled-content> chromatin\u2013remodelling complex. Previously, we identified a novel hotspot mutation in B<\/jats:styled-content>rm in human skin cancer, which is caused by exposure to ultraviolet radiation (UVR<\/jats:styled-content>). As SWI<\/jats:styled-content>\/SNF<\/jats:styled-content> is involved in DNA<\/jats:styled-content> repair, we investigated whether B<\/jats:styled-content>rm\u2212\/\u2212 mice had enhanced photocarcinogenesis. P53+\/\u2212 and B<\/jats:styled-content>rm\u2212\/\u2212p53+\/\u2212 mice were also examined as the p53 tumor suppressor gene is mutated early during human skin carcinogenesis. Mice were exposed to a low\u2010dose irradiation protocol that caused few skin tumors in wild\u2010type mice. B<\/jats:styled-content>rm\u2212\/\u2212 mice with both p53 alleles intact had an increased incidence of skin and ocular tumors compared to B<\/jats:styled-content>rm+\/+p53+\/+ controls. B<\/jats:styled-content>rm loss in p53+\/\u2212 mice did not further enhance skin or ocular cancer incidence beyond the increased photocarcinogenesis in p53+\/\u2212 mice. However, the skin tumors that arose early in B<\/jats:styled-content>rm\u2212\/\u2212 p53+\/\u2212 mice had a higher growth rate. B<\/jats:styled-content>rm\u2212\/\u2212 did not prevent UVR<\/jats:styled-content>\u2010induced apoptotic sunburn cell formation, which is a protective response. Unexpectedly, B<\/jats:styled-content>rm\u2212\/\u2212 inhibited UVR<\/jats:styled-content>\u2010induced immunosuppression, which would be predicted to reduce rather than enhance photocarcinogenesis. In conclusion, the absence of B<\/jats:styled-content>rm increased skin and ocular photocarcinogenesis. Even when one allele of p53 is lost, B<\/jats:styled-content>rm has additional tumor suppressing capability.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2012.01522.x","type":"journal-article","created":{"date-parts":[[2012,5,2]],"date-time":"2012-05-02T06:31:34Z","timestamp":1335940294000},"page":"599-604","source":"Crossref","is-referenced-by-count":18,"title":["The absence of B<\/scp>rm exacerbates photocarcinogenesis"],"prefix":"10.1111","volume":"21","author":[{"given":"Gary M.","family":"Halliday","sequence":"first","affiliation":[{"name":"Discipline of Dermatology Bosch Institute Sydney Medical School University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhou","sequence":"additional","affiliation":[{"name":"Discipline of Dermatology Bosch Institute Sydney Medical School University of Sydney Sydney NSW Australia"},{"name":"Dermatology Department Hebei General Hospital Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Sou","sequence":"additional","affiliation":[{"name":"Discipline of Dermatology Bosch Institute Sydney Medical School University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao X. J.","family":"Huang","sequence":"additional","affiliation":[{"name":"Discipline of Dermatology Bosch Institute Sydney Medical School University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabita","family":"Rana","sequence":"additional","affiliation":[{"name":"Discipline of Dermatology Bosch Institute Sydney Medical School University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Bugeja","sequence":"additional","affiliation":[{"name":"Discipline of Dermatology Bosch Institute Sydney Medical School University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Painter","sequence":"additional","affiliation":[{"name":"Discipline of Dermatology Bosch Institute Sydney Medical School University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Scolyer","sequence":"additional","affiliation":[{"name":"Tissue Pathology and Diagnostic Oncology Royal Prince Alfred Hospital Sydney Sydney NSW Australia"},{"name":"Discipline of Pathology Sydney Medical School University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Muchardt","sequence":"additional","affiliation":[{"name":"Unit of Epigenetic Regulation Institut Pasteur Paris Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Di Girolamo","sequence":"additional","affiliation":[{"name":"School of Medical Sciences University of New South Wales Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Guy Lyons","sequence":"additional","affiliation":[{"name":"Discipline of Dermatology Bosch Institute Sydney Medical School University of Sydney Sydney NSW Australia"},{"name":"Sydney Cancer Centre Royal Prince Alfred Hospital Sydney Head and Neck Cancer Institute Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(01)00198-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91685-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01257.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmec.2008.04.005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202789"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.1.274"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.319"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10267.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.04.026"},{"key":"e_1_2_9_11_1","first-page":"560","volume":"63","author":"Reisman D N","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0489"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2601"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20521"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/07357900802563010"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.23.6979"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00002-6"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.00261.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070517"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.121"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401141101"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1794"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2725"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-1988"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161210791033923"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.374"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.2741\/ullrich"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000941"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01197.x"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0625.2012.01522.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0625.2012.01522.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T21:24:47Z","timestamp":1698701087000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0625.2012.01522.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,10]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1111\/j.1600-0625.2012.01522.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0625.2012.01522.x","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,10]]}}}