{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:24:55Z","timestamp":1791559495858,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,7,10]],"date-time":"2012-07-10T00:00:00Z","timestamp":1341878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fluoxetine, a member of the class of selective serotonin reuptake inhibitors, is a potent antidepressant commonly used in clinical practice. Here, we report that fluoxetine increases cellular tyrosinase (<jats:styled-content style=\"fixed-case\">TYR<\/jats:styled-content>) activity, enhances the protein levels of microphthalmia\u2010associated transcription factor (<jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">TYR<\/jats:styled-content> and tyrosinase\u2010related protein\u20101 (<jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content>\u20101) and eventually leads to a dramatic increase in melanin production in both murine <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>16<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>10 melanoma cells and normal human melanocytes (<jats:styled-content style=\"fixed-case\">NHMC<\/jats:styled-content>s). In well\u2010characterized <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mouse models, systemic application of fluoxetine increased hair pigmentation by up\u2010regulating hair follicular <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> TYR<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> TRP<\/jats:styled-content>\u20101 and tyrosinase\u2010related protein\u20102 (<jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content>\u20102) protein levels. Using a serotonin 1<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> receptor (<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>) antagonist and <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> interference (<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>i) technique, we revealed that <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>1A appears to be one of the involved pathways in the fluoxetine\u2010induced melanogenesis in B16F10 cells. These results suggest that fluoxetine may hold a significant therapeutic potential for treating skin hypopigmentation disorders, and <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>1A may serve as a novel target in modulating melanogenesis.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2012.01531.x","type":"journal-article","created":{"date-parts":[[2012,5,10]],"date-time":"2012-05-10T14:24:19Z","timestamp":1336659859000},"page":"635-637","source":"Crossref","is-referenced-by-count":23,"title":["Up\u2010regulation of melanin synthesis by the antidepressant fluoxetine"],"prefix":"10.1111","volume":"21","author":[{"given":"Sha","family":"Liao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical 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