{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:55:00Z","timestamp":1790074500968,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,7,10]],"date-time":"2012-07-10T00:00:00Z","timestamp":1341878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"Abstract<\/jats:title>The miRNA<\/jats:styled-content> expression profiles of skin biopsies from 14 primary cutaneous anaplastic large cell lymphoma (C\u2010ALCL<\/jats:styled-content>) patients were analysed with miRNA<\/jats:styled-content> microarrays using the same control group of 12 benign inflammatory dermatoses (BID<\/jats:styled-content>) as previously used to study the miRNA<\/jats:styled-content> expression profile of tumor\u2010stage mycosis fungoides (MF<\/jats:styled-content>). We identified 13 differentially expressed miRNA<\/jats:styled-content>s between C<\/jats:styled-content>\u2010ALCL<\/jats:styled-content> and BID<\/jats:styled-content>. The up\u2010regulation of miR<\/jats:styled-content>\u2010155, miR<\/jats:styled-content>\u201027b, miR<\/jats:styled-content>\u201030c and miR<\/jats:styled-content>\u201029b in C<\/jats:styled-content>\u2010ALCL<\/jats:styled-content> was validated by miRNA<\/jats:styled-content>\u2010Q<\/jats:styled-content>\u2010PCR<\/jats:styled-content> on independent study groups. Additionally, the miRNA<\/jats:styled-content> expression profiles of C<\/jats:styled-content>\u2010ALCL<\/jats:styled-content> were compared with those of tumor\u2010stage MF<\/jats:styled-content>. Although miRNA<\/jats:styled-content> microarray analysis did not identify statistically significant differentially expressed miRNA<\/jats:styled-content>s, miRNA<\/jats:styled-content>\u2010Q<\/jats:styled-content>\u2010PCR<\/jats:styled-content> demonstrated statistically significantly differential expression of miR<\/jats:styled-content>\u2010155, miR<\/jats:styled-content>\u201027b, miR<\/jats:styled-content>\u201093, miR<\/jats:styled-content>\u201029b and miR<\/jats:styled-content>\u201092a between tumor\u2010stage MF<\/jats:styled-content> and C<\/jats:styled-content>\u2010ALCL<\/jats:styled-content>. This study, the first describing the miRNA<\/jats:styled-content> expression profile of C<\/jats:styled-content>\u2010ALCL<\/jats:styled-content>, reveals differences with tumor\u2010stage MF<\/jats:styled-content>, suggesting a different contribution to the pathogenesis of these lymphomas.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2012.01548.x","type":"journal-article","created":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T17:55:27Z","timestamp":1339091727000},"page":"632-634","source":"Crossref","is-referenced-by-count":44,"title":["Primary cutaneous anaplastic large cell lymphoma shows a distinct miRNA<\/scp> expression profile and reveals differences from tumor\u2010stage mycosis fungoides"],"prefix":"10.1111","volume":"21","author":[{"given":"Marchina F.","family":"Benner","sequence":"first","affiliation":[{"name":"Department of Dermatology LUMC Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Ballabio","sequence":"additional","affiliation":[{"name":"Lymphoid Malignancy Research Group Nuffield Department of Clinical Laboratory Sciences John Radcliffe Hospitals University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marloes S.","family":"van Kester","sequence":"additional","affiliation":[{"name":"Department of Dermatology LUMC Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel J.","family":"Saunders","sequence":"additional","affiliation":[{"name":"Sir William Dunn School of Pathology University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten H.","family":"Vermeer","sequence":"additional","affiliation":[{"name":"Department of Dermatology LUMC Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rein","family":"Willemze","sequence":"additional","affiliation":[{"name":"Department of Dermatology LUMC Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"Lawrie","sequence":"additional","affiliation":[{"name":"Lymphoid Malignancy Research Group Nuffield Department of Clinical Laboratory Sciences John Radcliffe Hospitals University of Oxford Oxford UK"},{"name":"Biodonostia Research Institute Paseo Doctor Begiristain s\/n, San Sebasti\u00e1n Spain"},{"name":"IKERBASQUE Basque Foundation for Science Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis P.","family":"Tensen","sequence":"additional","affiliation":[{"name":"Department of Dermatology LUMC Leiden The 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