{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:12:52Z","timestamp":1793059972938,"version":"4.5.0"},"reference-count":74,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,8,7]],"date-time":"2012-08-07T00:00:00Z","timestamp":1344297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hidradenitis suppurativa (\n                    <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                    ) is an inflammatory, debilitating follicular skin disease with recurring flare\u2010ups. The painful, deep\u2010seated, inflamed lesions in the inverse areas of the body cause severe discomfort, and hence, serious psycho\u2010social and economic costs.\n                    <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                    is common, but often misdiagnosed and mechanistically poorly understood. Furthermore,\n                    <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                    is notoriously difficult to treat resulting in a high unmet medical need. To provoke debate, rational experimentation and initiate strategic studies, we here present a concise viewpoint on seven topics: the diagnosis of\n                    <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                    , the role of mechanical friction, the critical importance of accurate clinical subgrouping, smoking and obesity, the role of bacteria, and our comprehensive view on\n                    <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                    pathogenesis with a central role for keratin clearance, and novel treatment approaches.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0625.2012.01552.x","type":"journal-article","created":{"date-parts":[[2012,6,20]],"date-time":"2012-06-20T09:04:19Z","timestamp":1340183059000},"page":"735-739","source":"Crossref","is-referenced-by-count":171,"title":["Hidradenitis suppurativa: viewpoint on clinical phenotyping, pathogenesis and novel treatments"],"prefix":"10.1111","volume":"21","author":[{"given":"Hessel H.","family":"van der Zee","sequence":"first","affiliation":[{"name":"Department of Dermatology Erasmus MC University Medical Center Rotterdam The Netherlands"},{"name":"Department of Immunology Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon D.","family":"Laman","sequence":"additional","affiliation":[{"name":"Department of Immunology Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurr","family":"Boer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Deventer Hospital Deventer The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Errol P.","family":"Prens","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erasmus MC University Medical Center Rotterdam The Netherlands"},{"name":"Department of Immunology Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90321-7"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.06.020"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08282.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.061"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1082"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00712_1.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-33101-8_3"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.1.162"},{"key":"e_1_2_12_10_1","first-page":"534","volume":"33","author":"Krauspe C","year":"1962","journal-title":"Chirurg"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-009-1207-2"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/17.4.810"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-0170-8"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2010.07.027"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09430.x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1990.tb06264.x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000287261"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01443.x"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2000.00087.x"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01088.x"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700272"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.01058.x"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2867"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327923"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000018126"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09198.x"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(00)00051-X"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(97)00551-3"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-961816"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04640.x"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03290.x"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.02.007"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00062209"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.01050.x"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01224.x"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-49-7-675"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03054.x"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.194"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.06.005"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21463"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800751011"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800731210"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.00043.x"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0736-4679(86)90214-3"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1975.01360070069012"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.02.013"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05485"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2921"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1159\/000246246"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02613.x"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2537"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10254.x"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00915.x"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10698.x"},{"key":"e_1_2_12_55_1","first-page":"729","volume-title":"Dermatologic surgery","author":"Hurley H J","year":"1989"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05390.x"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03377.x"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10071.x"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.328"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2010.03.005"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09491.x"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.07.010"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04123.x"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1990.01670270071012"},{"key":"e_1_2_12_65_1","first-page":"289P","volume":"88","author":"Buckley D A","year":"1995","journal-title":"J R Soc Med"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2005.01983.x"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986711794088407"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000209787.19952.53"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190802005191"},{"key":"e_1_2_12_70_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.5070\/D34PH5R1M2","volume":"16","author":"Reddick C L","year":"2010","journal-title":"Dermatol Online J"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.1.669"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2004.11.003"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03389.x"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100977"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.9.4781"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0625.2012.01552.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0625.2012.01552.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0625.2012.01552.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:11:40Z","timestamp":1695481900000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0625.2012.01552.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,7]]},"references-count":74,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1111\/j.1600-0625.2012.01552.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0625.2012.01552.x","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,7]]}}}