{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:39:58Z","timestamp":1790419198272,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T00:00:00Z","timestamp":1345161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ectopic mineralization, linked to a number of diseases, is a major cause of morbidity and mortality in humans. Pseudoxanthoma elasticum (<jats:styled-content style=\"fixed-case\">PXE<\/jats:styled-content>) is a heritable multisystem disorder characterized by calcium phosphate deposition in various tissues. The mineral content of diet has been suggested to modify the disease severity in <jats:styled-content style=\"fixed-case\">PXE<\/jats:styled-content>. The aim of this study is to explore the role of diet with reduced magnesium in modifying tissue mineralization in a mouse model of <jats:styled-content style=\"fixed-case\">PXE<\/jats:styled-content>. <jats:italic>Abcc6<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice were placed on either standard rodent diet (control) or an experimental diet low in magnesium at weaning (4\u00a0weeks) and examined for mineralization in the skin and internal organs at the ages of 1.5, 2 or 6\u00a0months by computerized morphometric analysis of histopathological sections and by chemical assay of calcium and phosphate. <jats:italic>Abcc6<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice on experimental diet demonstrated an accelerated, early\u2010onset mineralization of connective tissues, as compared to control mice. Wild\u2010type or heterozygous mice on experimental diet did not show evidence of mineralization up to 6\u00a0months of age. All mice on experimental diet showed decreased urinary calcium, increased urinary phosphate and elevated parathyroid serum levels. However, no difference in bone density at 6\u00a0months of age was noted. Our findings indicate that the mineral content, particularly magnesium, can modify the extent and the onset of mineralization in <jats:italic>Abcc6<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice and suggest that dietary magnesium levels may contribute to the phenotypic variability of <jats:styled-content style=\"fixed-case\">PXE<\/jats:styled-content>. The control of mineralization by dietary magnesium may have broader implications in general population in the context of vascular mineralization.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2012.01553.x","type":"journal-article","created":{"date-parts":[[2012,6,22]],"date-time":"2012-06-22T16:25:08Z","timestamp":1340382308000},"page":"694-699","source":"Crossref","is-referenced-by-count":56,"title":["Restricting dietary magnesium accelerates ectopic connective tissue mineralization in a mouse model of pseudoxanthoma elasticum <i>(Abcc6<\/i><sup><i>\u2212\/\u2212<\/i><\/sup><i>)<\/i>"],"prefix":"10.1111","volume":"21","author":[{"given":"Qiujie","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology, Jefferson Medical College and Jefferson Institute of Molecular Medicine Thomas Jefferson University Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouni","family":"Uitto","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology, Jefferson Medical College and Jefferson Institute of Molecular Medicine Thomas Jefferson University Philadelphia PA 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