{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T19:41:46Z","timestamp":1778960506223,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T00:00:00Z","timestamp":1345161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ulcerative dermatitis (<jats:styled-content style=\"fixed-case\">UD<\/jats:styled-content>) is a severe inflammatory skin disorder with an unknown aetiology. Recently, insulin receptor substrate 1 <jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content> mice were shown to be fully resistant to <jats:styled-content style=\"fixed-case\">UD<\/jats:styled-content>. In this study, we showed that high\u2010fat diet (<jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content>) feeding significantly increased incidence of <jats:styled-content style=\"fixed-case\">UD<\/jats:styled-content> in wild type (<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>) C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mice, as did lithium\u2010mediated inhibition of <jats:styled-content style=\"fixed-case\">GSK<\/jats:styled-content>3\u2010\u03b2, which is a key negative regulator of <jats:styled-content style=\"fixed-case\">IRS<\/jats:styled-content>1. In contrast to <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> mice, resistance to <jats:styled-content style=\"fixed-case\">UD<\/jats:styled-content> was fully preserved in <jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content>\u2010fed <jats:styled-content style=\"fixed-case\"><jats:italic>Irs1<\/jats:italic><\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content> mice. Our results identify <jats:styled-content style=\"fixed-case\">IRS<\/jats:styled-content>1 as a key determinant of <jats:styled-content style=\"fixed-case\">UD<\/jats:styled-content> pathogenesis and establish a direct link between diet composition, obesity\u2010induced inflammation and chronic ulceration.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2012.01558.x","type":"journal-article","created":{"date-parts":[[2012,6,25]],"date-time":"2012-06-25T13:50:00Z","timestamp":1340632200000},"page":"712-713","source":"Crossref","is-referenced-by-count":12,"title":["Experimental analysis of risk factors for ulcerative dermatitis in mice"],"prefix":"10.1111","volume":"21","author":[{"given":"Brit","family":"Neuhaus","sequence":"first","affiliation":[{"name":"Max Planck Institute for Biology of Ageing Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carien M.","family":"Niessen","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of 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