{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:19:48Z","timestamp":1788394788127,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T00:00:00Z","timestamp":1345161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Histamine facilitates development of eczematous lesions in chronic allergic contact dermatitis. In addition to the well\u2010known corticosteroid treatments, <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>1 receptor (<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>) antagonists also have been used. This study observed effects of histamine <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>4 receptor (<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>4<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>) antagonist usage with <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content> antagonist in a murine chronic allergic contact dermatitis model, developed by repeated percutaneous challenge to the dorsal skin with 2,4,6\u2010trinitro\u20101\u2010chlorobenzene (<jats:styled-content style=\"fixed-case\">TNCB<\/jats:styled-content>). The <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content> antagonist olopatadine hydrochloride and\/or the <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>4<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content> antagonist <jats:styled-content style=\"fixed-case\">JNJ<\/jats:styled-content>7777120 was then administered. Combination therapy was more effective than <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content> antagonist monotherapy. Serum <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> and levels of interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20104, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20105 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h2 cytokines) in eczematous lesions decreased with combined therapy. Combined therapy with <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content> and H4R antagonists counteracts the disadvantages of each as monotherapeutic agents and potentially represents a new strategy for the treatment of chronic allergic contact dermatitis.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2012.01559.x","type":"journal-article","created":{"date-parts":[[2012,6,25]],"date-time":"2012-06-25T13:50:01Z","timestamp":1340632201000},"page":"714-715","source":"Crossref","is-referenced-by-count":27,"title":["Advantages of histamine <scp>H<\/scp>4 receptor antagonist usage with <scp>H<\/scp>1 receptor antagonist for the treatment of murine allergic contact dermatitis"],"prefix":"10.1111","volume":"21","author":[{"given":"Ayuko","family":"Matsushita","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition Science Sagami Women's Junior College Bunkyo Minamiku Sagamihara Kanagawa 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