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Inflammasome assembly results in caspase\u20101 activation, which in turn drives maturation and secretion of the pro\u2010inflammatory cytokines interleukin 1\u03b2 (IL\u20101\u03b2) and IL\u201018, and induces pyroptosis to eliminate the infectious agent. The importance of inflammasomes in regulating immune responses was recognized with the discovery of polymorphisms in genes encoding inflammasome components and their linkage to aberrant production of IL\u20101\u03b2 and IL\u201018 in autoimmune and hereditary periodic fevers syndromes. 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