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In the case of the two major pathogenic human retroviruses, human immunodeficiency virus\u20101 (HIV\u20101) and human T\u2010lymphotrophic virus\u2010I (HTLV\u2010I), the nuclear factor\u2010\u03baB (NF\u2010\u03baB) transcription factor plays a key role in the host\u2019s anti\u2010viral responses involving both the innate and adaptive arms of the immune response. Similarly, these retroviruses capably exploit NF\u2010\u03baB for their replication, spread, and pathogenic functions. In this review, we discuss the dynamic and intimate interplay that occurs between NF\u2010\u03baB and the HTLV\u2010I and HIV\u20101 retroviral pathogens.<\/jats:p>","DOI":"10.1111\/j.1600-065x.2012.01094.x","type":"journal-article","created":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T00:08:53Z","timestamp":1332461333000},"page":"286-310","source":"Crossref","is-referenced-by-count":88,"title":["Dynamic roles for NF\u2010\u03baB in HTLV\u2010I and HIV\u20101 retroviral pathogenesis"],"prefix":"10.1111","volume":"246","author":[{"given":"Jonathan K.","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warner 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