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Tfh differentiation is driven by expression of the transcriptional repressor B\u2010cell lymphoma\u20106 (Bcl\u20106), which turns on a program that guides T cells close to B\u2010cell areas where Tfh cells first provide help to B cells. Sustained Bcl\u20106 expression promotes the entry of Tfh cells into follicles and modulates their cytokine expression profile so they can support and select germinal center B cells that have acquired affinity\u2010enhancing mutations in their immunoglobulin genes. Forkhead box 3 protein (Foxp3)<jats:sup>+<\/jats:sup> regulatory T cells and invariant natural killer T (NKT) cells can also co\u2010opt the Bcl\u20106\u2010dependent follicular differentiation pathway to migrate into B\u2010cell follicles and regulate antibody responses. The resulting NKT follicular helper cells drive a distinctive type of T\u2010dependent B\u2010cell response to lipid\u2010containing antigens, whereas FoxP3<jats:sup>+<\/jats:sup> follicular regulatory (Tfr) cells exert a suppressive function on germinal centers. 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