{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T05:04:59Z","timestamp":1696655099948},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,2,2]],"date-time":"2004-02-02T00:00:00Z","timestamp":1075680000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> An effective vaccine against human immunodeficiency virus (HIV) should not only protect from infection and development of acquired immunodeficiency syndrome (AIDS), but also prevent potential transmission to na\u00efve partners. We recently reported protection of rhesus macaques from chronic simian\u2010human immunodeficiency virus (SHIV) infection and AIDS by an HIV envelope peptide\u2010cocktail vaccine. In the present case study, we observed that one of the vaccinated females, with undetectable circulating virus, when housed in a pair with a na\u00efve male, did not transmit the infection over a 35\u2010week period of social contact. Subsequent experimental challenge of the male with the same SHIV strain resulted in high\u2010level infection and transmission to its female cage\u2010mate. However, the virus was undetectable in the female by 12\u2003weeks without further vaccination, validating the multivalent peptide cocktail vaccine approach in the SHIV\u2010rhesus model, and suggesting its potential utility as an HIV vaccine strategy for humans.<\/jats:p>","DOI":"10.1111\/j.1600-0684.2003.00050.x","type":"journal-article","created":{"date-parts":[[2007,2,10]],"date-time":"2007-02-10T00:15:56Z","timestamp":1171066556000},"page":"10-15","source":"Crossref","is-referenced-by-count":3,"title":["SHIV transmission and susceptibility to re\u2010exposure through social contact following vaccination with an HIV synthetic peptide\u2010cocktail: a case study"],"prefix":"10.1111","volume":"33","author":[{"given":"Lori R.","family":"Hill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pramod N.","family":"Nehete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Schapiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharti P.","family":"Nehete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Jagannadha Sastry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,2]]},"reference":[{"key":"e_1_2_14_2_2","volume-title":"Patterns of Primate Behavior","author":"Bramblett CA","year":"1994"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-198911000-00015"},{"key":"e_1_2_14_4_2","first-page":"195","article-title":"Sexual transmission and transmission by biting of SIVagm among captive green monkeys, Cercopithecus aethiops sabaeus","volume":"62","author":"Diop O","year":"1994","journal-title":"Folia Primatol"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199007000-00002"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0684.1996.tb00023.x"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/79626"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0684.1996.tb00198.x"},{"key":"e_1_2_14_9_2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1600-0684.1992.tb00594.x","article-title":"Transmission of SIVMne from female to male Macaca nemestrina","volume":"21","author":"Kuller L","year":"1992","journal-title":"J Med Primatol"},{"key":"e_1_2_14_10_2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1600-0684.1990.tb00445.x","article-title":"Effect of virus dose and nonoxynol \u2013 9 on the genital transmission of SIV in rhesus macaques","volume":"19","author":"Miller CJ","year":"1990","journal-title":"J Med Primatol"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00408-X"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0684.2003.00011.x"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1998.14.785"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0684.1994.tb00088.x"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/319293"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1998.14.183"},{"key":"e_1_2_14_17_2","first-page":"157","article-title":"Ecology and social organization of African tropical forest primates: aid in understanding retrovirus transmission","volume":"93","author":"Tutin CE","year":"2000","journal-title":"Bull Soc Pathol Exot"}],"container-title":["Journal of Medical Primatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0684.2003.00050.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0684.2003.00050.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T22:34:32Z","timestamp":1696631672000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0684.2003.00050.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["10.1111\/j.1600-0684.2003.00050.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0684.2003.00050.x","archive":["Portico"],"relation":{},"ISSN":["0047-2565","1600-0684"],"issn-type":[{"value":"0047-2565","type":"print"},{"value":"1600-0684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,2]]}}}