{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:08:04Z","timestamp":1762916884430},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,3,17]],"date-time":"2004-03-17T00:00:00Z","timestamp":1079481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> The Indian langur monkey (<jats:italic>Presbytis entellus<\/jats:italic>) is an experimental host for a range of human diseases and for the assessment of vaccine candidate antigens to some common parasitic infections. This experimental host is particularly suitable for the follow\u2010up of immunological responses. To understand some of the mechanism that underlies the defense against experimental pathogens there is a need of the basic knowledge on antibody and cell mediated immune responses. In the present study 25 na\u00efve monkeys were subjected to for assessment of their antibody responses to various human parasitic antigens as well as mitogen induced cellular responses. Only few monkeys were found to have low titer of antiparasitic antibodies. There was compressive dose dependent proliferative response of peripheral blood mononuclear cells. Unlike humans, the blastogenic as well as cytokine responses (IFN\u2010<jats:italic>\u03b3<\/jats:italic>, IL\u20102 and IL\u20104) to Con A was considerably higher as compared to PHA. These findings are similar to what have been reported in other non\u2010human primates, confirming the appropriateness of Indian langurs for pre\u2010clinical trials.<\/jats:p>","DOI":"10.1111\/j.1600-0684.2004.00045.x","type":"journal-article","created":{"date-parts":[[2004,3,17]],"date-time":"2004-03-17T15:53:42Z","timestamp":1079538822000},"page":"65-69","source":"Crossref","is-referenced-by-count":3,"title":["Immune responses in normal Indian langur monkeys (<i>Presbytis entellus<\/i>) \u2013 a primate model for visceral leishmaniasis"],"prefix":"10.1111","volume":"33","author":[{"given":"Alka","family":"Misra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Dube","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Naik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,3,17]]},"reference":[{"key":"e_1_2_13_2_2","first-page":"63","article-title":"The Indian langur: preliminary report of a new non\u2010human primate host for visceral leishmaniasis","volume":"70","author":"Anuradha D","year":"1992","journal-title":"Bull WHO"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/1988633224"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0684.1995.tb00175.x"},{"key":"e_1_2_13_5_2","first-page":"57","article-title":"ICRC vaccine\u2010induced changes in M. leprae\u2010specific cell\u2010mediated immunity in langur (Presbytis entellus) monkeys","volume":"54","author":"Chirmule NB","year":"1986","journal-title":"Int J Lepr Other Mycobact Dis"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.2307\/3278484"},{"key":"e_1_2_13_7_2","first-page":"267","article-title":"Small species of primates in biomedical research","volume":"18","author":"Cooper RW","year":"1968","journal-title":"Lab Anim Care"},{"key":"e_1_2_13_8_2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.4269\/ajtmh.1976.25.299","article-title":"Schistosoma mansoni in baboons. 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