{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T23:12:03Z","timestamp":1762125123366},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,12,22]],"date-time":"2004-12-22T00:00:00Z","timestamp":1103673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Since its discovery nearly 30\u2003years ago platelet\u2010activating factor (PAF) has emerged as one of the more important lipid mediators known. PAF (1\u2010<jats:italic>O<\/jats:italic>\u2010alkyl\u20102\u2010<jats:italic>O<\/jats:italic>\u2010acetyl\u2010<jats:italic>sn<\/jats:italic>\u2010glycero\u20103\u2010phosphorylcholine) exists endogenously as a mixture of molecular species with structural variants of the alkyl moiety. PAF is a novel potent signaling phospholipid that has unique pleiotropic biological properties in addition to platelet activation. PAF also plays a significant role in reproduction and is present in the sperm of a number of primate species. PAF content in squirrel monkey sperm is significantly higher during the breeding season than the non\u2010breeding season. PAF content in rhesus sperm has a significant relationship with sperm motility. PAF content in human sperm has a positive correlation with seminal parameters and pregnancy outcomes. The enzymes (lyso\u2010PAF\u2010acetyltransferase and PAF\u2010acetylhydrolase) necessary for PAF activation and deactivation are present in primate sperm. PAF\u2010acetylhydrolase may act as a \u2018decapacitation factor\u2019. Removal of this enzyme during capacitation promotes PAF synthesis increasing primate motility and fertilization. PAF also plays a significant role in the fertilization process, enhancing the fertilization rates of oocytes. Enhanced embryo development has also been reported in oocytes fertilized with PAF\u2010treated sperm. Exogenous PAF will also significantly improve primate artificial insemination pregnancy outcomes. PAF antagonists inhibit sperm motility, acrosome reaction, and fertilization thus suggesting the presence of receptors for PAF. The PAF\u2010receptor is present on primate sperm, with altered transcript levels and distribution patterns on abnormal cells. Whereas, the exact mechanism of PAF in sperm function and reproduction is uncertain, its importance in normal primate fertility is substantial.<\/jats:p>","DOI":"10.1111\/j.1600-0684.2004.00087.x","type":"journal-article","created":{"date-parts":[[2004,12,23]],"date-time":"2004-12-23T01:06:30Z","timestamp":1103763990000},"page":"20-24","source":"Crossref","is-referenced-by-count":15,"title":["The significance of platelet\u2010activating factor and fertility in the male primate: a review"],"prefix":"10.1111","volume":"34","author":[{"given":"William E.","family":"Roudebush","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe B.","family":"Massey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlene W.","family":"Elsner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel 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