{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:11:52Z","timestamp":1773011512797,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,3,3]],"date-time":"2006-03-03T00:00:00Z","timestamp":1141344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Severe disseminated vasculopathy was observed in two simian immunodeficiency virus (SIV)\u2010infected rhesus macaques (<jats:italic>Macaca mulatta<\/jats:italic>). These animals developed clinical signs of AIDS, including lymphadenopathy, weight loss, diarrhea and collapse.<\/jats:p><jats:p><jats:bold>Results and discussion\u2002<\/jats:bold> Grossly, both animals showed emaciation, lymphadenopathy, vegetations on the mitral valve, renal infarcts and a dilated intestine; one animal had multifocal hemorrhages in multiple organs. Histologically, both cases had disseminated arteriopathy characterized by intimal thickening and fibrosis with varying degrees of vasculitis. The lesion was prominent in the kidney, intestine, pancreas, liver, heart, lymph nodes, spleen and testis. Occasional venules had intimal thickening. Both cases had cytomegalovirus (CMV) infection with intranuclear inclusions, CMV antigen and nucleic acid; some inclusions were observed in endothelial cells within some of the vascular lesions in one of the two. These data suggest that CMV caused the unusual lesions.<\/jats:p>","DOI":"10.1111\/j.1600-0684.2005.00145.x","type":"journal-article","created":{"date-parts":[[2006,3,3]],"date-time":"2006-03-03T14:30:43Z","timestamp":1141396243000},"page":"106-112","source":"Crossref","is-referenced-by-count":16,"title":["Systemic arteriopathy in SIV\u2010infected rhesus macaques (<i>Macaca mulatta<\/i>)"],"prefix":"10.1111","volume":"35","author":[{"given":"Tokuma","family":"Yanai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew A.","family":"Lackner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Masegi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith A.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,3]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"345","article-title":"Disseminated cytomegalovirus infection in immunodeficient rhesus monkeys","volume":"129","author":"Baskin GB","year":"1987","journal-title":"Am J Pathol"},{"key":"e_1_2_5_3_2","first-page":"338","article-title":"Arteriopathy in macaques infected with simian immunodeficiency virus","volume":"67","author":"Chalifoux LV","year":"1992","journal-title":"Lab Invest"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.1.335"},{"key":"e_1_2_5_5_2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/jama.1989.03420240075030","article-title":"Cytomegalovirus infection is associated with cardiac allograft rejection and atherosclerosis","volume":"261","author":"Grattan MT","year":"1989","journal-title":"J Am Med Assoc"},{"key":"e_1_2_5_6_2","first-page":"1195","article-title":"Viral pathogenesis of atherosclerosis. 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