{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:30:31Z","timestamp":1790033431011,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,2,14]],"date-time":"2006-02-14T00:00:00Z","timestamp":1139875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold>  \n          An intravascular stroke model designed for magnetic resonance imaging was developed in <jats:italic>Macaca fascicularis<\/jats:italic> (<jats:italic>M. fascicularis<\/jats:italic>) to characterize serial stroke lesion evolution. This model produces a range of stroke lesion sizes which closely mimics human stroke evolution. This paper describes the care of animals undergoing this stroke procedure, the range of outcomes we experienced and the cause of mortality in this model.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Anesthesia was induced with atropine and ketamine and maintained with isoflurane or propofol. Non\u2010invasive blood pressure, oxygen saturation, heart rate, respiration rate, temperature and end tidal CO<jats:sub>2<\/jats:sub> were monitored continuously. The stroke was created by occluding a distal branch of the middle cerebral artery. During catheter placement animals were heparinized and vasospasm was minimized using verapamil.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Anesthetic induction and maintenance were smooth. Animals with small strokes showed very rapid recovery, were able to ambulate and self\u2010feed within 2\u2003hours of recovery. Animals with strokes of \u22654% of the hemispheric volume required lengthy observation during recovery and parenteral nutrition. Large strokes resulted in significant brain edema, herniation and brainstem compression.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Intracerebral hemorrhage and or subarachnoid hemorrhage coupled with a stroke of any size was acutely fatal. In the absence of an effective acute stroke therapy, the spectrum of outcomes seen in our primate model is very similar to that observed in human stroke patients.<\/jats:p>","DOI":"10.1111\/j.1600-0684.2006.00147.x","type":"journal-article","created":{"date-parts":[[2006,2,14]],"date-time":"2006-02-14T08:56:03Z","timestamp":1139907363000},"page":"78-86","source":"Crossref","is-referenced-by-count":27,"title":["Middle cerebral artery occlusion in <i>Macaca fascicularis<\/i>: acute and chronic stroke evolution"],"prefix":"10.1111","volume":"35","author":[{"given":"Helen E.","family":"D'Arceuil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Duggan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Pryor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"de Crespigny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,14]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012743170-3\/50043-1"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012743170-3.50044-3"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2004.12.005"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.7.1456"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.44.2.96"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012743170-3\/50173-4"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1996.00550040037012"},{"key":"e_1_2_7_9_2","first-page":"1013","article-title":"Functional CT perfusion imaging in predicting the extent of cerebral infarction from a 3\u2010hour middle cerebral arterial occlusion in a primate stroke model","volume":"23","author":"Hamberg LM","year":"2002","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_7_10_2","first-page":"423","article-title":"Diffusion\u2010weighted MR imaging of acute stroke: correlation with T2\u2010weighted and magnetic susceptibility\u2010enhanced MR imaging in cats","volume":"11","author":"Moseley ME","year":"1990","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198704000-00002"},{"key":"e_1_2_7_12_2","volume-title":"Veterinary Drug Handbook","author":"Plumb DC","year":"1999"},{"key":"e_1_2_7_13_2","first-page":"162","article-title":"Proton magnetic resonance imaging in experimental cerebral ischaemia","volume":"43","author":"Rijen PC","year":"1988","journal-title":"Acta Neurochir Suppl (Wien)"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.15.3.492"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198009000-00009"}],"container-title":["Journal of Medical Primatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0684.2006.00147.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0684.2006.00147.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:08:35Z","timestamp":1698710915000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0684.2006.00147.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,14]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1111\/j.1600-0684.2006.00147.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0684.2006.00147.x","archive":["Portico"],"relation":{},"ISSN":["0047-2565","1600-0684"],"issn-type":[{"value":"0047-2565","type":"print"},{"value":"1600-0684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,14]]}}}