{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T07:38:19Z","timestamp":1698824299360},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,10]],"date-time":"2006-07-10T00:00:00Z","timestamp":1152489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Human mydriatric drug use in non\u2010human primates (NHPs) has been documented but not quantified and compared for effectiveness. The objective of this study was to determine which drug regimen provided the most effective and consistent mydriatic effect for ophthalmologic examinations and other procedures. Secondary objectives were to determine average time to maximum dilation and whether species differences existed.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Twelve rhesus and 12 African green monkeys were randomly assigned to one of six treatment combinations to test the mydriatic effects of three drug regimens: (1) tropicamide 1% (T); (2) tropicamide 1% and phenylephrine hydrochloride 2.5% (TP); and (3) tropicamide 1%, phenylephrine HCL 2.5% and cyclopentolate 1% (TPC). Left and right eyes of each monkey received a different drug regimen, depending on random assignment.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> TPC showed a significantly larger mydriatic response in both species than T alone. Average time to maximum dilation with all three drug regimens was 50\u201360\u2003minutes. Rhesus had a larger response to the mydriatic drug regimens than the African green monkeys.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> The TPC regimen had the largest and longest lasting mydriatic effect in both species.<\/jats:p>","DOI":"10.1111\/j.1600-0684.2006.00176.x","type":"journal-article","created":{"date-parts":[[2006,7,10]],"date-time":"2006-07-10T13:49:03Z","timestamp":1152539343000},"page":"33-38","source":"Crossref","is-referenced-by-count":3,"title":["Effects of three mydriatic drug regimens on pupil size in rhesus (<i>Macaca mulatta<\/i>) and African green monkeys (<i>Chlorocebus aethiops<\/i>)"],"prefix":"10.1111","volume":"36","author":[{"given":"N.L.","family":"Merrill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Burge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,10]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"524","volume-title":"Textbook of Veterinary Internal Medicine, Vol 1, 4th edn","author":"Clerc B","year":"1995"},{"key":"e_1_2_6_3_2","first-page":"49","volume-title":"International Perspectives, The Future of Nonhuman Primate Resources","author":"Ervin F","year":"2003"},{"key":"e_1_2_6_4_2","first-page":"430","volume-title":"Manual of Ocular Diagnosis & Therapy, 5th edn","author":"Pavan\u2010Langston D.","year":"2002"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3928\/0191-3913-19861101-04","article-title":"A comparison of the pupillary and cardiovascular effects of various mydriatic agents in preterm infants","volume":"23","author":"Sindel BD","year":"1986","journal-title":"Pediatr Ophthalmol Strabismus"},{"key":"e_1_2_6_6_2","first-page":"475","volume-title":"Martindale\u2014The Complete Drug Reference, 34th edn","author":"Sweetman SC.","year":"2005"},{"key":"e_1_2_6_7_2","first-page":"1043","volume-title":"Drug Information for the Health Care Professional","author":"United State Pharmacopeia Dispensing Information","year":"2005"}],"container-title":["Journal of Medical Primatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0684.2006.00176.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0684.2006.00176.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T07:51:37Z","timestamp":1698738697000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0684.2006.00176.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,10]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1600-0684.2006.00176.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0684.2006.00176.x","archive":["Portico"],"relation":{},"ISSN":["0047-2565","1600-0684"],"issn-type":[{"value":"0047-2565","type":"print"},{"value":"1600-0684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,10]]}}}