{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T05:03:47Z","timestamp":1698728627944},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,10,9]],"date-time":"2006-10-09T00:00:00Z","timestamp":1160352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Case history\u2002<\/jats:bold> A 4\u2010year\u2010old chimpanzee (<jats:italic>Pan troglodytes<\/jats:italic>) had a clinical history of a 2\u2010year progressive central nervous dysfunction including convulsions and severe paralysis.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Gross pathology revealed cerebral atrophy, ventricular enlargement and a severe encephalomalacia with extensive calcifications. Histologically, the white matter showed diffuse demyelination as well as vascular and perivascular calcifications which also involved the basal ganglia. Blood vessels with less distinctive calcium deposits exhibited periodic acid Schiff positive hyalinosis. Large areas of necrosis, hemorrhage and intense gliosis were also present. Activation of astrocytes and macrophages was confirmed by immunohistochemical methods.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> The etiology of the leucoencepalopathy could not be ascertained by macroscopic, histological and immunohistochemical examinations. Potential differential diagnoses include the rarely occurring Fahr's disease in humans, arteriosclerosis, storage disease and the Aicardi\u2013Gouti\u00e8res syndrome. Based on the results of the postmortal examinations Fahr's disease is regarded as the most likely diagnosis in the present case of the chimpanzee.<\/jats:p>","DOI":"10.1111\/j.1600-0684.2006.00199.x","type":"journal-article","created":{"date-parts":[[2006,10,9]],"date-time":"2006-10-09T14:13:28Z","timestamp":1160403208000},"page":"385-390","source":"Crossref","is-referenced-by-count":4,"title":["Leucoencephalopathy with cerebral calcinosis in a young chimpanzee (<i>Pan troglodytes<\/i>) \u2013 a case 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