{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:07:16Z","timestamp":1773144436560,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2008,2,4]],"date-time":"2008-02-04T00:00:00Z","timestamp":1202083200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> A cynomolgus macaque (<jats:italic>Macaca fascicularis<\/jats:italic>) presented with decreased appetite, lethargy, ataxia, disorientation and visual impairment. It was used in a hepatitis B (HBV) study involving injections of HBV plasmid construct (450\u2003\u03bcg) and aflatoxin B1 (25\u2003\u03bcg\/kg) in an effort to develop a model of liver cirrhosis and hepatocellular carcinoma.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> The case work\u2010up included physical examination, including assessment of hydration, thoracic and abdominal radiographs and abdominal ultrasound. Clinical pathology included complete blood counts and tests for levels of plasma ammonia (NH<jats:sub>3<\/jats:sub>) and serum electrolytes, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, total bilirubin, and gamma\u2010glutamyl transferase. Serum samples had also been serially tested for the presence of HBsAg, anti\u2010HBc antibodies, HBV e\u2010antigen, and HBV DNA. With a tentative diagnosis of hepatic encephalopathy, treatment with lactulose, antibiotics, and fluid therapy was initiated.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Clinical pathology and diagnostic imaging performed on the animal revealed no abnormalities except for the hyperammoniemia. Absence of HBV markers in the serum indicated unsuccessful inoculation. Not fully responding to therapeutic intervention, the animal was euthanized. Necropsy revealed fibrous peritoneal adhesions and an abscess in the cerebellopontine angle. Exudate culture indicated the presence of alpha\u2010hemolytic streptococcus, <jats:italic>Eubacterium lentum<\/jats:italic>, and <jats:italic>Bacteroides stercoris<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Brain abscesses are uncommon in non\u2010human primates. This case of cerebellar abscess is characterized by important features similar to that found in humans, including the presenting signs and the presence of the above\u2010cultured bacteria.<\/jats:p>","DOI":"10.1111\/j.1600-0684.2007.00254.x","type":"journal-article","created":{"date-parts":[[2008,2,4]],"date-time":"2008-02-04T12:14:50Z","timestamp":1202127290000},"page":"82-87","source":"Crossref","is-referenced-by-count":3,"title":["Cerebellar abscess in a cynomolgus macaque (<i>Macaca fascicularis<\/i>)"],"prefix":"10.1111","volume":"37","author":[{"given":"Jason So","family":"Villano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"Ogden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Goh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lai 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