{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:09:47Z","timestamp":1791036587742,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2008,2,4]],"date-time":"2008-02-04T00:00:00Z","timestamp":1202083200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thirty\u2010four (34) days after arrival at our facility, a recently imported rhesus macaque demonstrated a grade 4\/5 reaction to intradermal testing with mammalian old tuberculin and a strong positive response in a serum interferon gamma (IFN\u2010\u03b3) stimulation assay (Primagam<jats:sup>\u00ae<\/jats:sup>). The affected animal was euthanized to prevent further exposure of the other rhesus in the quarantine room. Necropsy revealed enlarged, caseating mediastinal lymph nodes. Further analysis confirmed the presence of <jats:italic>Mycobacterium tuberculosis<\/jats:italic> complex organisms. Strict isolation measures were initiated and intensive testing of all animals in the affected room began immediately. After 13\u2003weeks of additional testing, none of the animals in the room showed any positive response and all were released from quarantine. This case illustrates the importance of prolonged quarantine of non\u2010human primates (NHP) and illustrates the usefulness of serology\u2010based diagnostics as an adjunct to intradermal testing (molecular\u2010based diagnostics typically refers to polymerase chain reaction, whereas this assay is really serology based, even though it is an <jats:italic>in vitro<\/jats:italic> IFN\u2010\u03b3 stimulation assay). It also demonstrates that with proper isolation procedures, the spread of tuberculosis can be prevented in NHP facilities.<\/jats:p>","DOI":"10.1111\/j.1600-0684.2007.00266.x","type":"journal-article","created":{"date-parts":[[2008,2,4]],"date-time":"2008-02-04T12:14:50Z","timestamp":1202127290000},"page":"20-24","source":"Crossref","is-referenced-by-count":14,"title":["Diagnosis and prevention of dissemination of tuberculosis in a recently imported rhesus macaque (<i>Macaca mulatta<\/i>)"],"prefix":"10.1111","volume":"37","author":[{"given":"Steven T.","family":"Shipley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turhan","family":"Coksaygan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Charles G.","family":"McLeod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis J.","family":"DeTolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,2,4]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"337","article-title":"Primary cutaneous inoculation tuberculosis in the Macaca mulatta monkey","volume":"34","author":"Allen AM","year":"1958","journal-title":"Am J Pathol"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1159\/000459913","article-title":"Tuberculosis outbreak in rhesus monkeys immunosuppressed with antithymocyte globulin","volume":"7","author":"Fox JG","year":"1975","journal-title":"J Med Primatol"},{"key":"e_1_2_6_4_2","first-page":"86","article-title":"Diagnosis of tuberculosis in macaques, using whole\u2010blood in vitro interferon\u2010gamma (PRIMAGAM) testing","volume":"54","author":"Garcia MA","year":"2004","journal-title":"Comp Med"},{"key":"e_1_2_6_5_2","first-page":"578","article-title":"Outbreak of Mycobacterium bovis in a conditioned colony of rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques","volume":"54","author":"Garcia MA","year":"2004","journal-title":"Comp Med"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098588201907s02"},{"key":"e_1_2_6_7_2","first-page":"1192","article-title":"Immunologic abnormality in a group of Macaca arctoides with high mortality due to atypical mycobacterial and other disease processes","volume":"46","author":"Holmberg CA","year":"1985","journal-title":"Am J Vet Res"},{"key":"e_1_2_6_8_2","first-page":"729","article-title":"Misleading positive tuberculin reactions in a squirrel monkey colony","volume":"38","author":"Pierce DL","year":"1988","journal-title":"Lab Anim Sci"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/73.2.93"},{"key":"e_1_2_6_10_2","first-page":"157","volume-title":"Mycobacterium Infection in Zoo Animals","author":"Sesline DH","year":"1978"}],"container-title":["Journal of Medical Primatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0684.2007.00266.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0684.2007.00266.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T21:34:50Z","timestamp":1695764090000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0684.2007.00266.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":9,"journal-issue":{"issue":"s1","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1111\/j.1600-0684.2007.00266.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0684.2007.00266.x","archive":["Portico"],"relation":{},"ISSN":["0047-2565","1600-0684"],"issn-type":[{"value":"0047-2565","type":"print"},{"value":"1600-0684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}