{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:19:53Z","timestamp":1784830793207,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,7,30]],"date-time":"2008-07-30T00:00:00Z","timestamp":1217376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> A high incidence of heart disease, especially idiopathic cardiomyopathy (IC), is seen in chimpanzees (<jats:italic>Pan troglodytes<\/jats:italic>).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We reviewed clinical records and necropsy reports of 87 adult chimpanzees for possible causes of heart disease\/IC. We examined age, sex, cause of death, weight, diet, environment, infectious diseases, experimental uses and clinical pathology.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The overall prevalence of heart disease in chimpanzees was 67.81%; the prevalence of IC was 51.72%. The prevalence of IC was significantly higher in males (60.32%) than that in females (29.17%, <jats:italic>P<\/jats:italic>\u2003=\u20030.009). The prevalence of other heart disease was higher in females (25%) than that in males (12.70%, <jats:italic>P<\/jats:italic>\u2003=\u20030.165). Heart failure occurred in 47.13% of chimpanzees. Heart disease was the primary cause of death in 34.49% of chimpanzees; 29.88% died of unknown causes.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> We found no evidence that diet, environment, viral agents, experimental use or disease exposure contributed to the deaths resulting from IC in chimpanzees.<\/jats:p>","DOI":"10.1111\/j.1600-0684.2008.00307.x","type":"journal-article","created":{"date-parts":[[2008,7,30]],"date-time":"2008-07-30T13:34:28Z","timestamp":1217424868000},"page":"51-58","source":"Crossref","is-referenced-by-count":60,"title":["Spontaneous heart disease in the adult chimpanzee (<i>Pan troglodytes<\/i>)"],"prefix":"10.1111","volume":"38","author":[{"given":"Brittany M.","family":"Seiler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Dick 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