{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:27:02Z","timestamp":1784831222607,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,7,14]],"date-time":"2009-07-14T00:00:00Z","timestamp":1247529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Early diagnosis of simian tuberculosis (TB) is vital to prevent transmission of this disease. We evaluated the ability of the QuantiFERON\u2010TB Gold (In\u2010Tube Method) assay (QFG\u2010IT) to detect TB in chacma baboons (<jats:italic>Papio ursinus<\/jats:italic>).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Fifty\u2010one baboons were tested using the Tuberculin Skin Test (TST) and the QFG\u2010IT. Baboons testing positive, and animals exposed to infected individuals, were euthanised and subjected to necropsy. Selected tissues were processed for histopathology, mycobacterial culture and genetic speciation.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Tuberculosis was confirmed in one TST positive\/QFG\u2010IT positive animal and one TST negative\/QFG\u2010IT positive animal. One TST positive\/QFG\u2010IT negative animal and five TST negative\/QFG\u2010IT negative animals were confirmed uninfected following necropsy.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The QFG\u2010IT correctly detected TB in two baboons, including one TST negative individual and correctly identified six baboons as uninfected, including one TST positive individual. The QFG\u2010IT shows promise as a sensitive, specific test for TB in chacma baboons.<\/jats:p>","DOI":"10.1111\/j.1600-0684.2009.00367.x","type":"journal-article","created":{"date-parts":[[2009,7,14]],"date-time":"2009-07-14T04:11:50Z","timestamp":1247544710000},"page":"411-417","source":"Crossref","is-referenced-by-count":20,"title":["Detection of <i>Mycobacterium tuberculosis<\/i> infection in chacma baboons (<i>Papio ursinus<\/i>) using the QuantiFERON\u2010TB Gold (In\u2010Tube) assay"],"prefix":"10.1111","volume":"38","author":[{"given":"Sven D. 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