{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:19:56Z","timestamp":1784830796743,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,1,25]],"date-time":"2010-01-25T00:00:00Z","timestamp":1264377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> To understand immunological responses in chimpanzees vaccinated with live\u2010attenuated vaccine (oral polio vaccine; OPV), serum neutralizing antibodies against poliovirus types 1, 2, and 3 were investigated over time.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> The neutralizing antibody titers against poliovirus types 1, 2, and 3 were determined by microneutralization test using 100 ID<jats:sub>50<\/jats:sub> of poliovirus types 1, 2, and 3 (Sabin strains).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Neutralizing antibodies against poliovirus types 1, 2, and 3 were detected in 85.7%, 71.4%, and 65% of the serum from 42 chimpanzees tested 9\u2003years post\u2010vaccination. The neutralizing antibody titers in chimpanzees were similar to the documented levels in human studies as an indicator of vaccine efficacy.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> This study reveals persistence of neutralizing antibodies in chimpanzees for at least 9\u2003years after vaccination with OPV. This first study in chimpanzees provides useful information for the evaluation of the success of vaccination with OPV in other captive apes.<\/jats:p>","DOI":"10.1111\/j.1600-0684.2010.00400.x","type":"journal-article","created":{"date-parts":[[2010,1,25]],"date-time":"2010-01-25T07:38:20Z","timestamp":1264405100000},"page":"123-128","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of poliovirus antibody titers in orally vaccinated semi\u2010captive chimpanzees in Uganda"],"prefix":"10.1111","volume":"39","author":[{"given":"L.","family":"Mugisha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Pauli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Opuda\u2010Asibo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.O.","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.H.","family":"Leendertz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Diedrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,3,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a120686"},{"key":"e_1_2_6_3_2","first-page":"2323","volume-title":"Pathology of the Nervous System","author":"Bodian D","year":"1972"},{"key":"e_1_2_6_4_2","first-page":"234","article-title":"Differentiation of types of poliomyelitis viruses. 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