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Continuous telemetry, arterial blood gases, chest radiography, blood culture, and clinical pathology monitored disease progression.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Onset of fever, &gt;39\u00b0C detected by continuous telemetry, 52\u201380\u2003hours post\u2010exposure was the first sign of systemic disease and provides a distinct signal for treatment initiation. Secondary endpoints of disease severity include tachypnea measured by telemetry, bacteremia, extent of pneumonia imaged by chest x\u2010ray, and serum lactate dehydrogenase enzyme levels.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Inhaled <jats:italic>Y.\u00a0pestis<\/jats:italic> in the AGM results in a rapidly progressive and uniformly fatal disease with fever and multifocal pneumonia, serving as a rigorous test model for antibiotic efficacy studies.<\/jats:p>","DOI":"10.1111\/j.1600-0684.2010.00443.x","type":"journal-article","created":{"date-parts":[[2010,8,16]],"date-time":"2010-08-16T05:16:46Z","timestamp":1281935806000},"page":"6-17","source":"Crossref","is-referenced-by-count":26,"title":["Primary pneumonic plague in the African Green monkey as a model for treatment efficacy evaluation"],"prefix":"10.1111","volume":"40","author":[{"given":"R. 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