{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T17:24:13Z","timestamp":1767115453073},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T00:00:00Z","timestamp":1320883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Human African trypanosomiasis is associated with metabolic changes which have not been well characterized.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold>  <jats:italic>Chlorocebus aethiops<\/jats:italic> were experimentally infected with <jats:italic>Trypanosoma brucei rhodesiense<\/jats:italic> and late\u2010stage disease induced at 28\u2003days post\u2010infection. Ear prick blood for glucose determination and blood samples were obtained at weekly intervals for 56\u2003days. Analysis was carried out using dry chemistry analysis.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> In early infection, there was a significant increase in creatine kinase, while during early and transitional stage of infection there was a significant decrease in glucose and high\u2010density lipoprotein and an increase in triglyceride levels. In the late stage, there was a significant increase in both total cholesterol and LDL levels.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Further investigations should focus on levels of total cholesterol during the follow\u2010up period in curatively treated vervet monkeys. 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