{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:50:57Z","timestamp":1761663057689},"reference-count":72,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T00:00:00Z","timestamp":1334793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Previously, we demonstrated decreased expression of somatostatin mRNA in aged macaque brain, particularly in the prefrontal cortex. To investigate whether or not this age\u2010dependent decrease in mRNA is related to morphological changes, we analyzed somatostatin cells in the cerebra of aged Japanese macaques and compared them with those in rats and tree shrews, the latter of which are closely related to primates.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Brains of aged macaques, tree shrews, and rats were investigated by immunohistochemistry with special emphasis on somatostatin.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> We observed degenerating somatostatin\u2010immunoreactive cells in the cortices of aged macaques and tree shrews. Somatostatin\u2010immunoreactive senile plaque\u2010like structures were found in areas 6 and 8 and in the nucleus accumbens of macaques, as well as in the nucleus accumbens and the cortex of aged tree shrews, where amyloid accumulations were observed.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Somatostatin degenerations may be related to amyloid accumulations and may play roles in impairments of cognitive functions during aging.<\/jats:p>","DOI":"10.1111\/j.1600-0684.2012.00540.x","type":"journal-article","created":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T08:54:33Z","timestamp":1334825673000},"page":"147-157","source":"Crossref","is-referenced-by-count":23,"title":["Somatostatin\u2010immunoreactive senile plaque\u2010like structures in the frontal cortex and nucleus accumbens of aged tree shrews and Japanese macaques"],"prefix":"10.1111","volume":"41","author":[{"given":"Akiko","family":"Yamashita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eberhard","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Taira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takamitsu","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoharu","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,19]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(97)00559-7"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02043.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(87)90697-5"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(03)00094-3"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2008.01.014"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00508437"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0684.2003.00022.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902600205"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/288279a0"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)91936-X"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(02)00929-0"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2009.07.002"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(97)00172-1"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90254-I"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90324-9"},{"key":"e_1_2_6_17_2","first-page":"235","volume-title":"UFAW Handbook of the Care and Management of Laboratory Animals","author":"Fuchs E","year":"1999"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900010038"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/7.4.347"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2007.00932.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.2174\/187152408786848157"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90848-6"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01317-0"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(90)90182-X"},{"key":"e_1_2_6_25_2","first-page":"1075","article-title":"The neuropathological changes associated with normal brain aging","volume":"11","author":"Hof PR","year":"1996","journal-title":"Histol Histopathol"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.07.013"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(96)00240-4"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(03)43047-1"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.01.053"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.03.010"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.69.2.416"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/7.6.476"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10996"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2005.08.005"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-0618(03)00030-9"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2007.02.002"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1998.6838"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800007665"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003329"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02661"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.19.7518"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-2237-z"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2009.04.001"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01134.2007"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00047-0"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(80)90018-0"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm186"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/314090a0"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00596-X"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(98)00033-5"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0926-6410(98)00042-1"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.2174\/1567202043362117"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(99)00017-2"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(99)00017-2"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.3128605"},{"key":"e_1_2_6_56_2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0013-4694(98)00022-4","article-title":"The organization of the cortical motor system: new concepts","volume":"106","author":"Rizzolatti G","year":"1988","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/314092a0"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(80)90177-9"},{"key":"e_1_2_6_59_2","first-page":"1449","article-title":"Distribution of beta\/A4 protein and amyloid precursor protein in hereditary cerebral hemorrhage with amyloidosis\u2010Dutch type and Alzheimer\u2019s disease","volume":"142","author":"Rozemuller AJ","year":"1993","journal-title":"Am J Pathol"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1206"},{"key":"e_1_2_6_61_2","volume-title":"A Combined MRI and Histology: Atlas of the Rhesus Monkey Brain","author":"Saleem KS","year":"2007"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.20.9549"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.631"},{"key":"e_1_2_6_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.03.077"},{"key":"e_1_2_6_65_2","volume-title":"A Stereotaxic Brain Atlas of the Tree Shrew (Tupaia glis","author":"Tigges J","year":"1969"},{"key":"e_1_2_6_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(96)00080-7"},{"key":"e_1_2_6_67_2","first-page":"150","article-title":"Immunohistochemical study of cerebral amyloid angiopathy. II. Enhancement of immunostaining using formic acid pretreatment of tissue sections","volume":"133","author":"Vinters HV","year":"1988","journal-title":"Am J Pathol"},{"key":"e_1_2_6_68_2","volume-title":"The Neocortex of Macaca mulatta","author":"von Bonin G","year":"1947"},{"key":"e_1_2_6_69_2","first-page":"141","article-title":"A phylogenetic foundation for comparative mammalian genomics","volume":"12","author":"Waddell PJ","year":"2001","journal-title":"Genome Inform"},{"key":"e_1_2_6_70_2","first-page":"61","article-title":"Amyloid \u00df\u2010immunoractive structures in the brain of aged tree shrews","volume":"201","author":"Yamashita A","year":"2008","journal-title":"Neurosci Res (suppl)"},{"key":"e_1_2_6_71_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874609811003030230"},{"key":"e_1_2_6_72_2","first-page":"379","volume-title":"Primatology Today, Proceeding of XIII the congress of international primatological society","author":"Yamashita A","year":"1991"},{"key":"e_1_2_6_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(89)90012-6"}],"container-title":["Journal of Medical Primatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0684.2012.00540.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0684.2012.00540.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T06:35:18Z","timestamp":1698647718000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0684.2012.00540.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,19]]},"references-count":72,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1600-0684.2012.00540.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0684.2012.00540.x","archive":["Portico"],"relation":{},"ISSN":["0047-2565","1600-0684"],"issn-type":[{"value":"0047-2565","type":"print"},{"value":"1600-0684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,19]]}}}