{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:50:18Z","timestamp":1780447818816,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,7,13]],"date-time":"2004-07-13T00:00:00Z","timestamp":1089676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Oral lichen planus (OLP) is a frequent immunological chronic disease, having different clinical forms: asymptomatic and symptomatic. Symptomatic OLP has been palliated with topical corticosteroids with different levels of efficacy and safety. The purpose of this pilot phase II clinical trial was to determine the efficacy of mometasone furoate microemulsion upon the symptoms and signs of erosive\u2010ulcerative OLP.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Forty\u2010nine patients with clinical and histologically confirmed erosive\u2010ulcerative OLP were enrolled in this study (36 women and 13 men). Their average age was 56.4\u2003years (from 28 to 78). The treatment consisted of 0.1% mometasone furoate microemulsion mouthwash three times a day over 30\u2003days. Pain, erythema and ulceration were assessed after 15 and 30\u2003days of treatment. The data was processed and statistically analysed by student's <jats:italic>t<\/jats:italic>\u2010test for paired samples.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Mometasone caused a statistically significant reduction in pain (3.58 vs. 0.65, <jats:italic>P<\/jats:italic>\u2003=\u20030.0000). Treatment significantly reduced the surface area of erythema (155.2 vs. 21.9\u2003mm<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2003=\u20030.0001) and ulceration (30.7 vs. 7.3\u2003mm<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2003=\u20030.0000). None of these patients suffered severe adverse effects.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Mometasone furoate microemulsion is a safe and effective therapy in the treatment of symptomatic erosive\u2010ulcerative OLP.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2004.00213.x","type":"journal-article","created":{"date-parts":[[2004,7,13]],"date-time":"2004-07-13T07:53:27Z","timestamp":1089705207000},"page":"381-385","source":"Crossref","is-referenced-by-count":19,"title":["Efficacy of mometasone furoate microemulsion in the treatment of erosive\u2010ulcerative oral lichen planus: pilot study"],"prefix":"10.1111","volume":"33","author":[{"given":"J. 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