{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T22:48:06Z","timestamp":1788648486322,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,6,16]],"date-time":"2004-06-16T00:00:00Z","timestamp":1087344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSF), which are highly associated with areca use, are prevalent in most Asian countries. Matrix metalloproteinases (MMPs) are superfamily of metal\u2010dependent proteolytic enzymes, mediating the degradation of extracellular matrix. Insertion\/deletion (\u22121607 2G\u21921G) polymorphism has been described in the promoter region of the human matrix metalloproteinases\u20101 (<jats:italic>MMP\u20101<\/jats:italic>) genes, which cause an alteration in the transcriptional activity. This genotype is associated with risks of cancer genesis and metastasis. In this paper, we studied the relationship between such genotype and areca\u2010associated oral diseases.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Genomic DNA from the blood of OSCC (<jats:italic>n<\/jats:italic>\u2003=\u2003121), OSF (<jats:italic>n<\/jats:italic>\u2003=\u200358) cases and controls (<jats:italic>n<\/jats:italic>\u2003=\u2003147) were amplified by polymerase chain reaction (PCR)\u2010based genotyping. The OSCC were further grouped into buccal squamous cell carcinoma (BSCC) and non\u2010buccal suqmaous cell carcinoma (NBSCC), in accord with the site of involvement. The significance of the differences was assessed by Fisher's exact test.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The 2G genotype in <jats:italic>MMP\u20101<\/jats:italic> promoter was observed with a higher frequency in both OSCC (0.69, <jats:italic>P<\/jats:italic>\u2003=\u20030.06) and NBSCC (0.76, <jats:italic>P<\/jats:italic>\u2003=\u20030.03) cases compared with controls (0.63), with an odds ratio of 2.17 and 4.58, respectively. This genotype was not related to the risk of OSF. No other clinicopathologic parameter was associated with the genotypes in OSCC cases.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The results showed that 2G genotype in <jats:italic>MMP\u20101<\/jats:italic> promoter was associated with the risk of OSCC.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2004.00214.x","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T11:55:07Z","timestamp":1281614107000},"page":"323-326","source":"Crossref","is-referenced-by-count":32,"title":["Correlation between functional genotypes in the <i>matrix metalloproteinases\u20101<\/i> promoter and risk of oral squamous cell carcinomas"],"prefix":"10.1111","volume":"33","author":[{"given":"Shu\u2010Chun","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Yi","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen\u2010Wu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzong\u2010Ming","family":"Shieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Ji","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo\u2010Wei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,6,16]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2000.290403.x"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00131.x"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00133.x"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2002.310405.x"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00149-6"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345010800120601"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.17.1260"},{"key":"e_1_2_9_9_2","first-page":"4823","article-title":"Interstitial collagenases as markers of tumor progression","volume":"6","author":"Brinckerhoff CE","year":"2000","journal-title":"Clin Cancer Res"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80429-8"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1139\/y99-055"},{"key":"e_1_2_9_12_2","first-page":"5321","article-title":"A single nucleotide polymorphism in the matrix metalloproteinase\u20101 promoter creates an ETS binding site and augments transcription","volume":"58","author":"Rutter JL","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_9_13_2","first-page":"4225","article-title":"Correlation between expression of the matrix metalloproteinase\u20101 gene in ovarian cancers and an insertion\/deletion polymorphism in its promoter region","volume":"59","author":"Kanamori Y","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_9_14_2","first-page":"7825","article-title":"A single nucleotide polymorphism in the matrix metalloproteinase\u20101 promoter enhances lung cancer susceptibility","volume":"61","author":"Zhu Y","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10750"},{"key":"e_1_2_9_16_2","first-page":"2344","article-title":"Matrix metalloproteinase\u20101 promoter polymorphism 1G\/2G is correlated with colorectal cancer invasiveness","volume":"7","author":"Ghilardi G","year":"2001","journal-title":"Clin Cancer Res"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1998.372"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10916"}],"container-title":["Journal of Oral Pathology &amp; 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