{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:23:24Z","timestamp":1778754204082,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,7,13]],"date-time":"2004-07-13T00:00:00Z","timestamp":1089676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> The serum circulatory levels of apoptosis related molecules measured in patients with oral lichen planus (OLP) and healthy individuals in order to investigate possible alterations associated with the clinical forms of OLP.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Serum levels of tumor necrosis factor (TNF)\u2010<jats:italic>\u03b1<\/jats:italic>, soluble Fas (sFas) and Bcl\u20102 studied by enzyme\u2010linked immunosorbent assay in whole blood samples in 13 OLP reticular, 13 OLP atrophic\u2010erosive form patients and 26 healthy subjects.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Significantly elevated levels of TNF\u2010<jats:italic>\u03b1<\/jats:italic> and sFas detected in OLP patients as compared with controls. Serum concentrations of Bcl\u20102 although increased in 17\/26 patients, they were not statistically significant. Reticular OLP exhibited slightly elevated TNF\u2010<jats:italic>\u03b1<\/jats:italic> and significantly elevated Bcl\u20102 serum levels, compared with erosive OLP.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> These data suggest that a putative dysfunction in the Fas\/FasL mediated apoptosis might be involved in the OLP pathogenesis. A downregulation of Bcl\u20102 serum levels in the atrophic\u2010erosive OLP may be associated with promotion of the disease activity.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2004.00221.x","type":"journal-article","created":{"date-parts":[[2004,7,13]],"date-time":"2004-07-13T07:53:27Z","timestamp":1089705207000},"page":"386-390","source":"Crossref","is-referenced-by-count":45,"title":["Elevated serum levels of the apoptosis related molecules TNF\u2010<i>\u03b1<\/i>, Fas\/Apo\u20101 and Bcl\u20102 in oral lichen planus"],"prefix":"10.1111","volume":"33","author":[{"given":"A.","family":"Sklavounou\u2010Andrikopoulou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Chrysomali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Iakovou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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