{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T22:48:04Z","timestamp":1788648484980,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,7,13]],"date-time":"2004-07-13T00:00:00Z","timestamp":1089676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold>  <jats:italic>Matrix metalloproteinase\u20102<\/jats:italic> (<jats:italic>MMP\u20102<\/jats:italic>) can degrade extracellular matrix and basement membrane, and play an important role in the development and progression of multiple carcinomas, including oral squamous cell carcinoma (OSCC). A \u22121306<jats:italic>C<\/jats:italic>\u2192<jats:italic>T<\/jats:italic> polymorphism in the <jats:italic>MMP\u20102<\/jats:italic> promoter disrupts Sp1\u2010binding site, and results in reduction of transcriptional activity. This study aimed to assess the association of such genotype with the risk of OSCC and oral submucous fibrosis (OSF), which is a precancerous condition that exhibits excessive collagen production and etiologically links to areca use.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Genomic DNA from the blood samples of 121 OSCC cases, 58 OSF cases and 147 controls were amplified by polymerase chain reaction (PCR) and subjected to denaturing high\u2010performance liquid chromatography (dHPLC) analysis for genotyping. The OSCC were further classified into buccal squamous cell carcinoma (BSCC) and non\u2010buccal squamous cell carcinoma (NBSCC), according to the site of involvement. Fisher's exact test and unconditional logistic regression models were used for statistical analysis.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Subjects carrying <jats:italic>CC<\/jats:italic> genotype had nearly twofold increased risk for developing OSCC when comparing with <jats:italic>CT<\/jats:italic> or <jats:italic>TT<\/jats:italic> genotype. Subjects carrying <jats:italic>CC<\/jats:italic> genotype had more apparent risk (greater than fourfold) for developing NBSCC. However, no increase in risk for lymph node metastasis or advanced stage was identified in OSCC cases carrying such genotype. Preliminarily data suggest no significant association between subjects carrying <jats:italic>CC<\/jats:italic> genotype and the development of BSCC or OSF.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> This is the first paper demonstrating that functional genotype of <jats:italic>MMP\u20102<\/jats:italic> promoter is a risk factor for oral carcinogenesis, particularly for the subsets occurring on non\u2010buccal site.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2004.00231.x","type":"journal-article","created":{"date-parts":[[2004,7,13]],"date-time":"2004-07-13T07:53:27Z","timestamp":1089705207000},"page":"405-409","source":"Crossref","is-referenced-by-count":43,"title":["Functional genotype in <i>matrix metalloproteinases\u20102<\/i> promoter is a risk factor for oral carcinogenesis"],"prefix":"10.1111","volume":"33","author":[{"given":"Shu\u2010Chun","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su\u2010Shun","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Ji","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Yi","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen\u2010Wu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo\u2010Wei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,7,13]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.31.21491"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc745"},{"key":"e_1_2_9_4_2","first-page":"3987","article-title":"A functional polymorphism in the matrix metalloproteinase\u20102 gene promoter (\u22121306C\/T) is associated with risk of development but not metastasis of gastric cardia adenocarcinoma","volume":"63","author":"Miao X","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010242200"},{"key":"e_1_2_9_6_2","first-page":"6430","article-title":"Correlation between a single nucleotide polymorphism in the matrix metalloproteinase\u20102 promoter and risk of lung cancer","volume":"62","author":"Yu C","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10916"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970106)70:1<120::AID-IJC18>3.0.CO;2-P"},{"key":"e_1_2_9_9_2","first-page":"699","article-title":"Active MMP2 in cancer cell nests of oral cancer patients: correlation with lymph node metastasis","volume":"13","author":"Kawamata H","year":"1998","journal-title":"Int J Oncol"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199910)21:7<627::AID-HED7>3.0.CO;2-2"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/99.1.18"},{"key":"e_1_2_9_12_2","first-page":"189","article-title":"Matrix metalloproteinase\u20102 and \u20109 activities correlate with the disease\u2010free survival of oral squamous cell carcinoma patients","volume":"20","author":"Yorioka CW","year":"2002","journal-title":"Int J Oncol"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20010120)95:1<44::AID-IJC1008>3.0.CO;2-M"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(98)00101-8"},{"key":"e_1_2_9_15_2","first-page":"55","article-title":"Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan","volume":"25","author":"Ko YC","year":"1995","journal-title":"J Oral Pathol Med"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00133.x"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2000.290403.x"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00131.x"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2004.00214.x"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2002.310405.x"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2003.121"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(01)00045-8"}],"container-title":["Journal of Oral Pathology &amp; 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