{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:52:10Z","timestamp":1761807130993},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> As the maintenance medium of the oral cavity, saliva is secreted from exocrine glands that include the parotid, submandibular, sublingual, and minor salivary glands. Considering that saliva is a fluid suffused with protein, it is possible that the solubilized by\u2010products of oncogenic expression may be present in saliva. Recent studies suggest the presence of solubilized extracellular domain portion of the c\u2010<jats:italic>erb<\/jats:italic>B\u20102 protein in serum, nipple aspirates, and saliva. As a consequence, the purpose of this study was to determine the presence and concentration of c\u2010<jats:italic>erb<\/jats:italic>B\u20102 in major salivary gland secretions.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Fifteen healthy women had serum, stimulated whole (SWS), parotid (SP), and submandibular\/sublingual (SS) salivary secretions collected. The specimens were analyzed for c\u2010<jats:italic>erb<\/jats:italic>B\u20102 using enzyme linked immunosorbent assays (ELISAs). Western blots using c\u2010<jats:italic>erb<\/jats:italic>B\u20102 were also performed on these specimens.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The ELISAs revealed the presence of c\u2010<jats:italic>erb<\/jats:italic>B\u20102 in SWS (24.50 Units\/ml), SP (19.66 Units\/ml), SS (15.59 Units\/ml) and serum (1472.15 Units\/ml). Western blots confirmed the presence of these 185\u2003kDa proteins.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> These results suggest that the protein, c\u2010<jats:italic>erb<\/jats:italic>B\u20102, is present in relatively equal amounts in both SP and SS glandular secretions. Elevated glandular salivary c\u2010<jats:italic>erb<\/jats:italic>B\u20102 concentrations could be useful as a preliminary, non\u2010invasive test in clinical decision making when diagnosing salivary gland carcinomas. Additionally, this marker may have utility in distinguishing between oral lesions that are benign, pre\u2010malignant and malignant in the oral cavity. Further research is required to determine if these findings have clinical utility.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2004.00255.x","type":"journal-article","created":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T15:53:58Z","timestamp":1097596438000},"page":"595-600","source":"Crossref","is-referenced-by-count":17,"title":["The expression of the c\u2010<i>erb<\/i>B\u20102 receptor protein in glandular salivary secretions"],"prefix":"10.1111","volume":"33","author":[{"given":"Charles 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