{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:15:11Z","timestamp":1779290111405,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,12,16]],"date-time":"2004-12-16T00:00:00Z","timestamp":1103155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> The aim of this study was to evaluate the effects of azithromycin on mucocutaneous manifestations, oral health and immune response in Beh\u00e7et's disease (BD).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Eight BD patients with active mucocutaneous symptoms were treated with azithromycin for 4\u2003weeks. Oral health, clinical manifestations and <jats:italic>in vitro<\/jats:italic> interleukin (IL)\u201012, interferon (IFN)\u2010<jats:italic>\u03b3<\/jats:italic>, IL\u201010 and monocyte chemotactic protein (MCP)\u20101 responses were evaluated before and after treatment.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The number of folliculitic lesions, healing time of oral ulcers and scores of plaque indexes (PLIs) were lower after azithromycin treatment (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Scores of PLIs correlated positively with the healing time of oral ulcers (<jats:italic>P<\/jats:italic>\u2003=\u20030.02). Although a trend towards increased stimulated IL\u201010 responses with azithromycin was observed, no statistically significant difference was found. Stimulated and unstimulated MCP\u20101, IFN\u2010<jats:italic>\u03b3<\/jats:italic> and IL\u201012 responses were similar before and after treatment (<jats:italic>P<\/jats:italic>\u2003&gt;\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Azithromycin was observed to be effective in decreasing folliculitic lesions and fastening the healing time of oral ulcers in BD.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2004.00265.x","type":"journal-article","created":{"date-parts":[[2004,12,16]],"date-time":"2004-12-16T12:15:17Z","timestamp":1103199317000},"page":"13-16","source":"Crossref","is-referenced-by-count":34,"title":["Clinical and immunological effects of azithromycin in Beh\u00e7et's disease"],"prefix":"10.1111","volume":"34","author":[{"given":"G.","family":"Mumcu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Ergun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Elbir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Eksioglu\u2010Demiralp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Yavuz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Atalay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Direskeneli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,12,16]]},"reference":[{"key":"e_1_2_11_2_2","first-page":"1","volume-title":"Rheumatology","author":"Yaz\u0131c\u0131 H","year":"1998"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.11.996"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(92)90207-6"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199909)42:9<1967::AID-ANR24>3.0.CO;2-Z"},{"key":"e_1_2_11_6_2","first-page":"1261","article-title":"Close association of Streptococcus sanguis and Beh\u00e7et's disease","volume":"95","author":"Yoshikawa K","year":"1991","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"e_1_2_11_7_2","first-page":"506","article-title":"Skin hypersensitivity of streptococal antigens and the induction of systemic symptoms by the antigens in Beh\u00e7et's Disease","volume":"16","author":"Mizushima Y","year":"1989","journal-title":"J Rheumatol"},{"key":"e_1_2_11_8_2","first-page":"1029","article-title":"Induction of Beh\u00e7et's disease symptoms after dental treatment and streptococcal antigen skin test","volume":"15","author":"Mizushima Y","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb02640.x"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh236"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000246336"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.1997.38.6.444"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(02)00323-1"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.9.960"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-199812000-00006"},{"key":"e_1_2_11_16_2","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et's disease","volume":"335","author":"International Study Group for Beh\u00e7et's disease","year":"1990","journal-title":"Lancet"},{"key":"e_1_2_11_17_2","first-page":"293","volume-title":"Clinical practice of the dental hygienist: indices and scoring methods","author":"Wilkins E.","year":"1999"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.12.1206"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.12.1449"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546630310012154"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.2.409-412.2002"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/46.1.19"},{"key":"e_1_2_11_23_2","first-page":"31","article-title":"Treatment of Beh\u00e7et's disease","volume":"4","author":"Hashimoto T","year":"1992","journal-title":"Curr Opin. 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