{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T02:38:14Z","timestamp":1711507094018},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Tuberculosis is one of the leading infectious diseases in the world, with more than 2\u2003million new cases annually. It is one of the main causes of death of human immunodeficiency virus (HIV)\u2010positive patients, involving multiple organs and particularly the lungs. Nevertheless there are few consistent studies about tuberculosis involving the parotid of HIV patients. The objective of this work was to describe the histological and immunohistochemical characteristics of 10 cases of mycobacteriosis involving the parotid of autopsied patients with advanced acquired immunodeficiency syndrome (AIDS), including identification of the <jats:italic>Mycobacterium<\/jats:italic> species.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Detection of \u2018<jats:italic>M. tuberculosis<\/jats:italic> complex\u2019 was performed by polymerase chain reaction (PCR) and ligase chain reaction (LCR) and <jats:italic>Mycobacterium avium<\/jats:italic> by PCR.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> All cases showed involvement of intraparotid lymph nodes, but the glandular parenchyma was affected in only three cases. Most of the cases (80%) presented a chronic non\u2010caseating granulomatous inflammation, and in two cases predominated foamy macrophages, full of bacteria, and no granuloma formation. In areas of mycobacteriosis, macrophages predominated followed by TCD8, B and TCD4 lymphocytes. All cases were infected by <jats:italic>Mycobacterium<\/jats:italic> genus and \u2018<jats:italic>M. tuberculosis<\/jats:italic> complex\u2019 was detected in five cases by LCR and in eight by PCR, while <jats:italic>M. avium<\/jats:italic> was positive in one case only, which was also positive for <jats:italic>M. tuberculosis<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Parotid mycobacteriosis in advanced AIDS is characterized by intraparotid lymph node non\u2010caseating inflammatory granulomatous lesion, caused mainly by <jats:italic>M. tuberculosis<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2005.00331.x","type":"journal-article","created":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T17:55:23Z","timestamp":1120240523000},"page":"407-412","source":"Crossref","is-referenced-by-count":12,"title":["Parotid mycobacteriosis is frequently caused by <i>Mycobacterium tuberculosis<\/i> in advanced AIDS"],"prefix":"10.1111","volume":"34","author":[{"given":"A. 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A.","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/165.6.1082"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.9.2.177"},{"key":"e_1_2_5_4_2","first-page":"67","article-title":"Tuberculosis of the parotid gland","volume":"45","author":"Janmeja AK","year":"2003","journal-title":"Indian J Chest Dis Allied Sci"},{"key":"e_1_2_5_5_2","first-page":"1080","article-title":"Young man with swelling of the left side of the neck and right testis","volume":"36","author":"Jakob AR","year":"1995","journal-title":"Internist (Berl)"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(98)70266-9"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100121863"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1128\/JCM.36.6.1512-1517.1998","article-title":"Evaluation of PCR in detection of Mycobacterium tuberculosis from formalin\u2010fixed, paraffin\u2010embedded tissues: comparison of four amplification assays","volume":"36","author":"Marchetti G","year":"1998","journal-title":"J Clin Microbiol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2003.02868.x"},{"key":"e_1_2_5_10_2","first-page":"914","article-title":"Rapid silver staining and recovery of PCR products separated on polyacrylamide gels","volume":"17","author":"Sanguinetti CJ","year":"1994","journal-title":"Biotechniques"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-997432"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1092-9134(98)80006-3"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.192.99"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.4.9802034"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/109.4.411"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762002000500024"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01461.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.44.11.924"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.44.2.115"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0714.2005.00331.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0714.2005.00331.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T06:43:10Z","timestamp":1697265790000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0714.2005.00331.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["10.1111\/j.1600-0714.2005.00331.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0714.2005.00331.x","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}