{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:01:02Z","timestamp":1782860462982,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Recurrent minor aphthous ulceration (RAU) is a common condition which is multifactorial in origin.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> This study, firstly, aimed to treat the prodromal stage of RAU with Aphtheal<jats:sup>TM<\/jats:sup> (5% amlexanox paste) to determine if ulcer development could be prevented. A second arm of the study investigated treatment of RAU with Aphtheal<jats:sup>TM<\/jats:sup> once ulceration had developed. Ulcer duration, ulcer size and associated pain were measured. Both groups of subjects had previously undergone a no\u2010treatment run\u2010in period to establish these parameters over an untreated episode of ulceration.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> By day 3, only 35% of the prodromal group had developed an ulcer compared with 97% of the ulcer group (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). In the treated ulcer group only 66% had an ulcer present by day 3. Treatment at the onset of prodromal symptoms reduced the maximum ulcer size score by 84% (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01), extent of ulceration by 88% (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01), maximum pain score by 69% (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01) and extent of pain by 85% (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01) compared to no treatment.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Treatment with Aphtheal<jats:sup>TM<\/jats:sup> at the onset of prodromal RAU symptoms can prevent progression to ulcer development and significantly reduced symptoms if ulcers do develop.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2005.00334.x","type":"journal-article","created":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T17:55:23Z","timestamp":1120240523000},"page":"413-419","source":"Crossref","is-referenced-by-count":36,"title":["A comparative study of the efficacy of Aphtheal<sup>TM<\/sup> in the management of recurrent minor aphthous ulceration"],"prefix":"10.1111","volume":"34","author":[{"given":"Brenda","family":"Murray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niall","family":"McGuinness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Biagioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Hyland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip\u2010John","family":"Lamey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,7]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"627","article-title":"Prevalence of recurrent herpes labialis and aphthous ulcers among young adults of six continents","volume":"113","author":"Embil JA","year":"1975","journal-title":"Can Med Assoc J"},{"key":"e_1_2_6_3_2","first-page":"329","article-title":"Association between recurrent aphthous ulcers and habits","volume":"93","author":"Axell T","year":"1985","journal-title":"Scand J Dent Res"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1992.0268"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70353-3"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(96)80403-3"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1970.0157"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1991.tb00952.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(91)90273-F"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1996.0412"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/10454411980090030401"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1085-5629(97)80017-X"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2004.08.001"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1991.tb00365.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(96)80403-3"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4809326"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(00)00147-4"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajot.2000.18872"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/58.1.41"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000233861"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(10)80164-8"},{"key":"e_1_2_6_22_2","first-page":"1116","article-title":"Amlexanox oral paste: a novel treatment that accelerates the healing of aphthous ulcers","volume":"18","author":"Binnie WH","year":"1997","journal-title":"Compend Cont Dent Edu"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(97)90009-3"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(97)90010-X"},{"key":"e_1_2_6_25_2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.2340\/0001555575264268","article-title":"Electronic infra\u2010red thermography as a method of assessing herpes labialis infection","volume":"75","author":"Biagioni PA","year":"1995","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb01187.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(99)00108-1"}],"container-title":["Journal of Oral Pathology &amp; 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