{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:42:42Z","timestamp":1773157362096,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,23]],"date-time":"2005-12-23T00:00:00Z","timestamp":1135296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Exposure to environmental carcinogens leads to oral squamous cell carcinoma (OSCC); however, the impact of genetic variations in carcinogen metabolisms and DNA repair on OSCC risk considering environmental exposures has not been clearly elucidated.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We conducted a case\u2013control study with 122 cases and 241 controls. The risk of OSCC was evaluated in 10 genetic polymorphisms of nine genes, such as <jats:italic>CYP1A1<\/jats:italic>, <jats:italic>CYP2E1<\/jats:italic>, <jats:italic>GSTM1<\/jats:italic>, <jats:italic>GSTT1<\/jats:italic>, <jats:italic>XPA<\/jats:italic>, <jats:italic>XPC<\/jats:italic>, <jats:italic>XPC<\/jats:italic>, <jats:italic>XPF<\/jats:italic> and <jats:italic>ERCC1<\/jats:italic>. Gene\u2013environment interaction was also evaluated.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> We found that <jats:italic>CYP2E1<\/jats:italic> and <jats:italic>XPA<\/jats:italic> polymorphisms significantly affected the OSCC risk. Gene\u2013environment interactions with smoking were significant for <jats:italic>CYP2E1<\/jats:italic> and <jats:italic>ERCC1<\/jats:italic> polymorphisms. Odds ratios for gene\u2013environment interaction were 7.98 (<jats:italic>P<\/jats:italic>\u2003=\u20030.036), 9.67 (<jats:italic>P<\/jats:italic>\u2003=\u20030.017) and 8.49 (<jats:italic>P<\/jats:italic>\u2003=\u20030.031) for <jats:italic>CYP2E1<\/jats:italic><jats:italic>Rsa<\/jats:italic>I, <jats:italic>Dra<\/jats:italic>I and <jats:italic>ERCC1<\/jats:italic> polymorphisms, respectively. No interaction was observed with heavy drinking and any polymorphisms.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>  <jats:italic>CYP2E1<\/jats:italic>, <jats:italic>XPA<\/jats:italic> and <jats:italic>ERCC1<\/jats:italic> polymorphisms may affect the risk of OSCC.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2005.00364.x","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T15:25:50Z","timestamp":1138029950000},"page":"11-18","source":"Crossref","is-referenced-by-count":95,"title":["Gene\u2013environment interaction involved in oral carcinogenesis: molecular epidemiological study for metabolic and DNA repair gene polymorphisms"],"prefix":"10.1111","volume":"35","author":[{"given":"Tomotaka","family":"Sugimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kumimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwai","family":"Tohnai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keitaro","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Tsurusako","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Mitsudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Tajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanji","family":"Ishizaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,23]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910340504"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(91)90022-G"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(91)90023-H"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/35077232"},{"key":"e_1_2_5_6_2","first-page":"1513","article-title":"Polymorphisms in DNA repair genes and associations with cancer risk","volume":"11","author":"Goode EL","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(00)00032-6"},{"key":"e_1_2_5_8_2","first-page":"465","article-title":"Reduced DNA repair capacity in head and neck cancer patients","volume":"7","author":"Cheng L","year":"1998","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10231"},{"key":"e_1_2_5_10_2","first-page":"901","article-title":"Genetic polymorphisms of CYP2E1, GSTM1, and GSTT1; 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