{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:34:10Z","timestamp":1760016850218},"reference-count":78,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,2,2]],"date-time":"2006-02-02T00:00:00Z","timestamp":1138838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold>Metastasic deposits from malignancies frequently lodge in the skeleton, including the jawbones.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold>A review of the literature was performed in order to provide a coherent overview on the pathogenesis of bone metastasis.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>Bone metastasis follows complex molecular interactions that enable tumor cells to detach from the primary site, invade the extracellular matrix, intravasate, extravasate, and proliferate within bone. They induce local bone changes that could manifest radiologically as either osteolytic or radiodense. In addition to the direct bone changes, malignancies can elaborate mediators that are released in circulation, leading to generalized osteopenia.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>The spread of malignant neoplasms to bone is not a random process but rather a cascade of specific molecular events orchestrated through complex interactions between neoplastic cells and their environment.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2006.00360.x","type":"journal-article","created":{"date-parts":[[2006,2,2]],"date-time":"2006-02-02T17:11:25Z","timestamp":1138900285000},"page":"129-135","source":"Crossref","is-referenced-by-count":33,"title":["Pathogenesis of bone metastasis: a review"],"prefix":"10.1111","volume":"35","author":[{"given":"E. J.","family":"Raubenheimer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. E. E.","family":"Noffke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2,2]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11127"},{"key":"e_1_2_10_3_2","first-page":"3","volume-title":"Bone tumors","author":"Dahlin DC","year":"1986"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90216-6"},{"key":"e_1_2_10_5_2","unstructured":"HirschbergA BuchnerA.Metastatic neoplasms to the oral cavity. Available at:http:\/\/www.emedicine.com\/derm\/topic673.htm. Last accessed 1 April 2002."},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.19.1.18"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00203395"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.108.6.2435"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.113.1.173"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1989.tb02336.x"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-4682(10)80013-3"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-7494-6_8"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.127.6.2061"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2006419"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201486"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/32433"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-419X(94)90003-5"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000227681"},{"key":"e_1_2_10_19_2","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1016\/S0021-9258(18)45911-X","article-title":"Identification, purification and partial sequence analysis of autotoxin, a novel motility\u2010stimulating protein","volume":"267","author":"Stracke M","year":"1992","journal-title":"J Biol Chem"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-61107-0_11"},{"key":"e_1_2_10_21_2","first-page":"11","article-title":"Scatter factor and hepatocyte growth factor: activities, properties and mechanism","volume":"3","author":"Bhargava M","year":"1992","journal-title":"Cell Growth Differ"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/327239a0"},{"key":"e_1_2_10_23_2","first-page":"519","article-title":"The molecular basis of skeletal metastases","volume":"4155","author":"Choong PFM.","year":"2003","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1230"},{"key":"e_1_2_10_25_2","first-page":"593","article-title":"The signalling network of tumor invasion","volume":"20","author":"Wang GK","year":"2005","journal-title":"Histol Histopathol"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0748-7983(96)80013-8"},{"key":"e_1_2_10_27_2","first-page":"741","article-title":"Expression of VLA\u2010alpha 6, and VLA\u2010beta 1 chains in normal mucosa and adenomas of the colon, and in colon carcinomas and their liver metastases","volume":"138","author":"Koretz K","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_10_28_2","first-page":"787","article-title":"Immunohistochemical localization of integrins in the normal, hyperplastic, and neoplastic breast: correlations with their functions as receptors and cell adhesion molecules","volume":"139","author":"Koukoulis GK","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.08.040190.002053"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm977"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1042\/bst0300207"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-002-8524-5"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00690603"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00046840"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200423823"},{"key":"e_1_2_10_36_2","first-page":"6758","article-title":"Chemotactic activity of endothelial cell\u2010derived interleukin\u20101 for human tumor cells","volume":"48","author":"Orr FW","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006715504719"},{"key":"e_1_2_10_38_2","first-page":"4613","article-title":"Rat prostate adenocarcinoma cells disseminate to bone and adhere preferentially to bone marrow\u2010denied endothelial cells","volume":"52","author":"Haq M","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(94)90703-X"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00132979"},{"key":"e_1_2_10_41_2","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0030-5898(20)31259-1","article-title":"The tissue pathological features of metabolic bone disease","volume":"15","author":"Vigorita VJ.","year":"1984","journal-title":"Orthop Clin North Am"},{"key":"e_1_2_10_42_2","doi-asserted-by":"crossref","first-page":"12665","DOI":"10.1016\/S0021-9258(18)67143-1","article-title":"Growth factors in bone matrix. Isolation of multiple types by chromatography on heparin\u2010sepharose","volume":"261","author":"Hauschka PV","year":"1986","journal-title":"J Biol Chem"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198012113032401"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199004193221603"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)49915-0"},{"key":"e_1_2_10_46_2","first-page":"3059","article-title":"Localization of parathyroid hormone\u2010related protein in breast cancer metastases: increased incidence in bone compared with other sites","volume":"51","author":"Powell GJ","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650070814"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.303.6816.1506"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02032890"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000093844.72468.f4"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000615)88:12 <2961::AID-CNCR12>3.0.CO;2-L"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000615)88:12 <2892::AID-CNCR2>3.0.CO;2-Y"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(95)03539-J"},{"key":"e_1_2_10_54_2","volume-title":"TGF\u2010\u03b2 stimulates PTHrP release from mammary cancer","author":"Firek A","year":"1994"},{"key":"e_1_2_10_55_2","first-page":"577","article-title":"Hypocalcemia due to avid calcium uptake by osteoblastic metastases of prostate cancer","volume":"163","author":"Szentirmai M","year":"1995","journal-title":"West J Med"},{"key":"e_1_2_10_56_2","first-page":"194","article-title":"Case report: Clinical hypocalcemia, the endocrine conference of the Alton Ochsner Medical Institutions and Tulane University Medical Center","volume":"19","author":"Weingand MC","year":"1994","journal-title":"Am J Med"},{"key":"e_1_2_10_57_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.106.5.1659"},{"key":"e_1_2_10_58_2","doi-asserted-by":"crossref","first-page":"6407","DOI":"10.1016\/S0021-9258(18)68800-3","article-title":"Latent high molecular weight complex of transforming growth factor\u2010\u03b21. Purification from human platelets and structural characterization","volume":"263","author":"Miyazano K","year":"1988","journal-title":"J Biol Chem"},{"key":"e_1_2_10_59_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.105.3.1039"},{"key":"e_1_2_10_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(90)90083-B"},{"key":"e_1_2_10_61_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.136.6.2397"},{"key":"e_1_2_10_62_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.136.5.2000"},{"key":"e_1_2_10_63_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-73-2-401"},{"key":"e_1_2_10_64_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.5.1009"},{"key":"e_1_2_10_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)38491-4"},{"key":"e_1_2_10_66_2","first-page":"2104","article-title":"Prostate specific antigen is a new favourable prognostic indicator for women with breast cancer","volume":"55","author":"Yu H","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_10_67_2","first-page":"164","article-title":"Biochemical analysis of prostate specific antigen\u2010proteolyzed insulin\u2010like growth factor binding protein\u20103","volume":"4","author":"Fielder PJ","year":"1994","journal-title":"Growth Regul"},{"key":"e_1_2_10_68_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1506"},{"key":"e_1_2_10_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65919-6"},{"key":"e_1_2_10_70_2","first-page":"2485","article-title":"HBGF\u20101 expression in normal rat prostate and two transplantable rat prostate tumors","volume":"49","author":"Mansson PE","year":"1989","journal-title":"Cancer Res"},{"issue":"1","key":"e_1_2_10_71_2","first-page":"S198","article-title":"Systemic fibroblast growth factor (GFG\u20101) prevents bone loss, increases new bone formation and restores trabecular microarchitecture in ovariectomized rats","volume":"10","author":"Dunstan CR","year":"1995","journal-title":"J Bone Miner Res"},{"key":"e_1_2_10_72_2","first-page":"898","article-title":"Bone: formation by autoinduction","volume":"151","author":"Urist MR.","year":"1965","journal-title":"Science"},{"key":"e_1_2_10_73_2","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/jbmr.5650090611","article-title":"Effect of transforming growth factor beta on bone nodule formation: expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase and type I collagen in mRNA long term cultures of fetal rat calvarial osteoblasts","volume":"9","author":"Harris SE","year":"1994","journal-title":"J Bone Miner Res"},{"key":"e_1_2_10_74_2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0022-5347(17)35534-9","article-title":"Endothelin\u20101 in the human prostate: tissue levels, source of production and isometric tension studies","volume":"151","author":"Langenstroer P","year":"1993","journal-title":"J Urol"},{"key":"e_1_2_10_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(90)90491-5"},{"key":"e_1_2_10_76_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.130.6.3617"},{"key":"e_1_2_10_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0995-944"},{"key":"e_1_2_10_78_2","first-page":"464","article-title":"Interleukin 6 stimulates the production of immunoreactive endothelin 1 in human breast cancer cells","volume":"53","author":"Yamashita J","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_10_79_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000093047.96273.4e"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0714.2006.00360.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0714.2006.00360.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T17:59:19Z","timestamp":1706896759000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0714.2006.00360.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,2]]},"references-count":78,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["10.1111\/j.1600-0714.2006.00360.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0714.2006.00360.x","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,2]]}}}