{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T22:48:04Z","timestamp":1788648484978,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T00:00:00Z","timestamp":1137715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Insertion\/deletion (\u22121171 5A\u21926A) polymorphisms in the promoter region of <jats:italic>matrix metalloproteinase 3<\/jats:italic> (<jats:italic>MMP3<\/jats:italic>) gene result in different transcriptional activities. MMP3 is able to degrade collagens types II, V, IX, and X, and other extracellular matrix. The functional promoter polymorphism of <jats:italic>MMP3<\/jats:italic> has been related to the susceptibility in some inflammatory diseases and metastasis of cancers.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Oral submucous fibrosis (OSF) and oral squamous cell carcinoma (OSCC) are prevalent among Asian areca users. In this study, genomic DNA obtained from the blood of OSCC (<jats:italic>n<\/jats:italic>\u2003=\u2003150), OSF (<jats:italic>n<\/jats:italic>\u2003=\u200371), and control non\u2010diseased areca user (<jats:italic>n<\/jats:italic>\u2003=\u200398) in male were subjected to polymerase chain reaction (PCR)\u2010based genotyping of <jats:italic>MMP3<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The 5A genotype in <jats:italic>MMP3<\/jats:italic> promoter was observed more frequently in OSF group than in control group (<jats:italic>P<\/jats:italic>\u2003=\u20030.01). No significant difference was noted between OSCC and control groups on the 5A genotype frequency (<jats:italic>P<\/jats:italic>\u2003=\u20030.18). No association was found between 5A genotype in <jats:italic>MMP3<\/jats:italic> promoter and site or lymph node metastasis and stage of OSCC.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The results indicated that the 5A genotype of <jats:italic>MMP3<\/jats:italic> promoter was associated with the risk of OSF but not OSCC.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2006.00370.x","type":"journal-article","created":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T14:16:08Z","timestamp":1137766568000},"page":"99-103","source":"Crossref","is-referenced-by-count":37,"title":["The functional (\u22121171 5A\u21926A) polymorphisms of <i>matrix metalloproteinase 3<\/i> gene as a risk factor for oral submucous fibrosis among male areca 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