{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T10:49:23Z","timestamp":1763808563171},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T00:00:00Z","timestamp":1137715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> The study was designed to determine the efficacy of OraDisc<jats:sup>TM<\/jats:sup> (active component 2\u2003mg amlexanox) on the prevention of aphthous ulcers treated at the prodromal stage.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Thermographic imaging was used to confirm the presence of a prodromal ulcer. Fifty\u2010two patients were randomized to receive OraDisc<jats:sup>TM<\/jats:sup> (<jats:italic>N<\/jats:italic>\u2003=\u200326) or vehicle patches (<jats:italic>N<\/jats:italic>\u2003=\u200326). Patches were applied four times a day for 72\u2003h over the prodromal area. The percentage of subjects who developed an ulcer at 72\u2003h was compared between groups using the Fisher's exact test.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> About 50% of subjects in the OraDisc<jats:sup>TM<\/jats:sup> group developed an ulcer by day 4 compared with 69% in the vehicle group. Erythema score, ulcer size, pain scores and thermographically active area and temperature all showed trends towards healing in the OraDisc<jats:sup>TM<\/jats:sup> group.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The OraDisc<jats:sup>TM<\/jats:sup> prevents ulcers from developing when compared with the vehicle patch.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2006.00379.x","type":"journal-article","created":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T14:16:08Z","timestamp":1137766568000},"page":"117-122","source":"Crossref","is-referenced-by-count":22,"title":["The efficacy of amelxanox OraDisc<sup>TM<\/sup> on the prevention of recurrent minor aphthous ulceration"],"prefix":"10.1111","volume":"35","author":[{"given":"B.","family":"Murray","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. A.","family":"Biagioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.\u2010J.","family":"Lamey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,20]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"627","article-title":"Prevalence of recurrent herpes labialis and aphthous ulcers among young adults of six continents","volume":"113","author":"Embil JA","year":"1975","journal-title":"Can Med Assoc J"},{"key":"e_1_2_5_3_2","first-page":"329","article-title":"Association between recurrent aphthous ulcers and habits","volume":"93","author":"Axell T","year":"1985","journal-title":"Scand J Dent Res"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1992.0268"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70353-3"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(96)80403-3"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1991.tb00952.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/10454411980090030401"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(94)90312-3"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1996.0412"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1085-5629(97)80017-X"},{"key":"e_1_2_5_12_2","first-page":"1130","volume-title":"Fitzpatrick's dermatology in general medicine","author":"Gallagher GT","year":"1999"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2004.08.001"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1991.tb00365.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(96)80403-3"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4809326"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(00)00147-4"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajot.2000.18872"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/58.1.41"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000233861"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(10)80164-8"},{"key":"e_1_2_5_22_2","first-page":"1116","article-title":"Amlexanox oral paste: a novel treatment that accelerates the healing of aphthous ulcers","volume":"18","author":"Binnie WH","year":"1997","journal-title":"Compend Contin Educ Dent"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(97)90009-3"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2005.00334.x"},{"key":"e_1_2_5_25_2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.2340\/0001555575264268","article-title":"Electronic infra\u2010red thermography as a method of assessing herpes labialis infection","volume":"75","author":"Biagioni PA","year":"1995","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/00015559850135832"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(97)90010-X"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0714.2006.00379.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0714.2006.00379.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T19:16:01Z","timestamp":1696965361000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0714.2006.00379.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,20]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1111\/j.1600-0714.2006.00379.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0714.2006.00379.x","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,20]]}}}