{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:03:46Z","timestamp":1789603426643,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T00:00:00Z","timestamp":1137715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold>The aim of this study was to analyse the usefulness of detecting important apoptosis and proliferation markers in assessing the biological potential of odontogenic keratocysts (OKC) and thus selecting the optimal diagnostic algorithm for these lesions.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>Indirect immunohistochemistry and relevant statistical methods were used for analysis of formalin\u2010fixed and paraffin\u2010embedded samples from 98 patients.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>Nevoid basal cell carcinoma syndrome (NBCCS) keratocysts were characterized by higher expression of Bcl\u20102, p27<jats:sup>Kip1<\/jats:sup>and c\u2010erbB\u20102 as well as by lower proliferative activity measured by Ki\u201067 in basal cell epithelium and by a lower inflammatory response in comparison with sporadic keratocysts. Dentigerous, radicular and non\u2010specified odontogenic cysts differed from both NBCCS and sporadic keratocysts in a wide spectrum of apoptosis and\/or cell cycle\u2010related protein expressions, higher proliferation in the basal cell layer, and vice versa, lower proliferation in the suprabasal cell layer.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>The NBCCS keratocysts have a different immunophenotype from sporadic keratocysts and both types are distinguishable from dentigerous, radicular and non\u2010specified odontogenic cysts. These findings confirm the separate biological potential of these lesions and the results of the immunohistochemical analysis have diagnostic and prognostic implications.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2006.00382.x","type":"journal-article","created":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T14:16:08Z","timestamp":1137766568000},"page":"75-80","source":"Crossref","is-referenced-by-count":59,"title":["Immunohistochemical analysis of the biological potential of odontogenic keratocysts"],"prefix":"10.1111","volume":"35","author":[{"given":"Zden\u011bk","family":"Kol\u00e1\u0159","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Geierov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Bouchal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jind\u0159ich","family":"Pazdera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edt\u011bzslav","family":"Zbo\u0159il","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Tvrd\u00fd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(01)00065-3"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2004.00014.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.9.1079"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198703000-00002"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0020.1999.283280314.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2003.0286"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2000.110814"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(02)00067-2"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.5858\/2004-128-313-MATDTO","article-title":"Molecular analysis to demonstrate that odontogenic keratocysts are neoplastic","volume":"128","author":"Agaram NP","year":"2004","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_11_2","first-page":"331","article-title":"Case report: Malignant transformation in odontogenic keratocysts","volume":"7","author":"Keszler A","year":"2002","journal-title":"Med Oral"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2001.19297"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345990780070901"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(01)00066-5"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200107000-00006"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(01)00067-7"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2000.8731"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100060050148"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2002.125199"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2000.290306.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1601-0825.1999.tb00304.x","article-title":"p53 and MDM2 expression in odontogenic cysts and tumours","volume":"5","author":"Carvalhais J","year":"1999","journal-title":"Oral Dis"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1517-74912002000200011"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200204000-00001"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2003.44.5.841"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2000.291001.x"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1354-523X.2003.00974.x"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2002.123496"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2004.04.017"}],"container-title":["Journal of Oral Pathology &amp; 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