{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:24:33Z","timestamp":1747614273900},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,3,3]],"date-time":"2006-03-03T00:00:00Z","timestamp":1141344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p><jats:bold>Backround:\u2002<\/jats:bold> The aim of the present study was to evaluate the diagnostic value of exfoliative cytology (EC) and DNA image cytometry applied to oral lesions of lichen planus (LP; <jats:italic>n<\/jats:italic>\u2003=\u200356), in order to detect or exclude malignant transformation.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Brush and excisional biopsies were obtained from 56 patients. In cases of oral LP in which brush biopsies were suspicious for tumor cells, nuclear DNA contents were measured, using a TV Image Analysis System.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In 50 patients EC yielded tumor cell\u2010negative, doubtful in four cases and suspicious results obtained in two cases. DNA image cytometry revealed DNA\u2010aneuploidy only in the two suspicious cases. The comparison between cytologic\/DNA\u2010cytometric diagnosis and biopsy histology resulted in a total agreement (LP without dysplasia: 54 and squamous cell carcinoma in LP: two cases).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> In conclusion, cytology with DNA\u2010cytometry is a highly sensitive, specific, and non\u2010invasive method, which can be used for periodical follow up of oral LP lesions in order to early detect or exclude malignancy.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2006.00401.x","type":"journal-article","created":{"date-parts":[[2006,3,3]],"date-time":"2006-03-03T15:23:09Z","timestamp":1141399389000},"page":"227-232","source":"Crossref","is-referenced-by-count":28,"title":["Cytologic and DNA\u2010cytometric examination of oral lesions in lichen planus"],"prefix":"10.1111","volume":"35","author":[{"given":"Dimitra","family":"Maraki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebnem","family":"Yalcinkaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Pomjanski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mosaad","family":"Megahed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred","family":"Boecking","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juergen","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,3]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"763","article-title":"Desquamative gingivitis: a clinical, histopathologic, and immunologic study","volume":"27","author":"Markopoulos AK","year":"1996","journal-title":"Quintessence Int"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1085-5629(97)80021-1"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.6.678"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(86)90100-3"},{"key":"e_1_2_5_6_2","first-page":"92","volume-title":"Oral pathology. 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