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The chemokine and chemokine receptor expressions in the epithelia were analyzed by DNA microarray.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>High levels of MIP\u20103<jats:italic>\u03b1<\/jats:italic>\/LARC\/CCL20 and its receptor CCR6 were expressed in the lesional epithelia. Furthermore, DC\u2010CK1\/CCL18, ELC\/CCL19, SDF\u20101\/CXCL12 and CXCR4 expressions were also increased. Immunohistologial analysis showed that high numbers of Langerhans cells (LCs) were present in the epithelia of OLP. Lesional epithelia also expressed high levels of the ligands specific for CXCR3 (e.g. MIG\/CXCL9, IP\u201010\/CXCL10 and I\u2010TAC\/CXCL11) and CCR5 (e.g. RANTES\/CCL5).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>Infiltration of LCs is orchestrated by CCR6. Further, LCs residing in the lesional epithelia may be a mature phenotype. Moreover, infiltration of T cells in OLP could be mediated by signaling pathways through CXCR3 and CCR5.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2006.00402.x","type":"journal-article","created":{"date-parts":[[2006,2,2]],"date-time":"2006-02-02T17:11:25Z","timestamp":1138900285000},"page":"167-174","source":"Crossref","is-referenced-by-count":61,"title":["Expression profile of chemokines and chemokine receptors in epithelial cell layers of oral lichen planus"],"prefix":"10.1111","volume":"35","author":[{"given":"Mana","family":"Ichimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Hiratsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadahiko","family":"Utsunomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Sakamaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshirou","family":"Kondoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimitsu","family":"Abiko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Otake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,2]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1990.tb00820.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1998.tb01926.x"},{"key":"e_1_2_5_4_2","first-page":"174","article-title":"Activation marker analysis of mononuclear cell infiltrates of oral lichen planus in situ","volume":"95","author":"Kilpi AM","year":"1987","journal-title":"Scand J Dent Res"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03355.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2001.70408.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1990.tb00866.x"},{"key":"e_1_2_5_8_2","first-page":"361","article-title":"Immunoelectron microscopic study of distribution of T cell subsets in oral lichen planus","volume":"97","author":"Jungell P","year":"1989","journal-title":"Scand J Dent Res"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1222"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/84219"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0031-6997(24)01439-X","article-title":"International union of pharmacology. 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