{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:03:21Z","timestamp":1787015001120,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,8,7]],"date-time":"2006-08-07T00:00:00Z","timestamp":1154908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p>\n                    <jats:bold>Background:\u2002<\/jats:bold>\n                    The aim of this study was to evaluate the efficacy of a topical hyaluronic acid (HA) preparation (0.2%) in the management of recurrent aphthous ulceration (RAU).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    One hundred and twenty patients with RAU participated in a randomized, placebo controlled, double\u2010blind trial to evaluate the efficacy of the topical HA and preparation. Outcome measures include soreness relief on immediate application (recorded over 60\u2003min). Thereafter, patients completed a log diary recording soreness from the ulcers, occurrence of new ulcers and ulcer duration.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    Both topical HA and placebo resulted in a significant reduction in ulcer soreness following immediate application (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030.0004). Throughout the rest of the investigation period, there was no significant differences (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003&gt;\u20030.05) between the treatments for reducing soreness. Patients treated with topical HA recorded few ulcers on day 5 of the investigation than those treated with placebo (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003&lt;\u20030.001). Likewise, the occurrence of new ulcers was lower in the HA treated group on day 4 when compared with placebo (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030.047).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:\u2002<\/jats:bold>\n                    Topical HA (0.2%) may be of benefit in the management of RAU. Immediate reduction of symptoms appears to be a barrier effect.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0714.2006.00433.x","type":"journal-article","created":{"date-parts":[[2006,8,7]],"date-time":"2006-08-07T05:40:51Z","timestamp":1154929251000},"page":"461-465","source":"Crossref","is-referenced-by-count":77,"title":["The efficacy of topical hyaluronic acid in the management of recurrent aphthous ulceration"],"prefix":"10.1111","volume":"35","author":[{"given":"A.","family":"Nolan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Baillie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Badminton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rudralingham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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